Effects of Hyperoxia on the Refraction in Murine Neonatal and Adult Models
Abstract
:1. Introduction
2. Results
2.1. Neonatal Hyperoxia Model Mice Showed Myopic Shift
2.2. Hyperoxia Induced Myopia in Adult Mice
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Experimental Design
4.2.1. Exposure to Highly Concentrated Oxygen
4.2.2. Ocular Components Measurement
4.2.3. Measurement of Lens Elasticity
4.3. Statistical Analyses
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
P8d | postnatal 8 days |
P6w | postnatal 6 weeks |
CR | corneal curvature radius |
AL | axial length |
ROP | retinopathy of prematurity |
OIR | oxygen-induced retinopathy |
CCT | central corneal thickness |
D | diopter |
ACD | anterior chamber depth |
LT | lens thickness |
kPa | kilopascal |
ROS | reactive oxidative species |
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Mori, K.; Kurihara, T.; Jiang, X.; Ikeda, S.-i.; Ishida, A.; Torii, H.; Tsubota, K. Effects of Hyperoxia on the Refraction in Murine Neonatal and Adult Models. Int. J. Mol. Sci. 2019, 20, 6014. https://doi.org/10.3390/ijms20236014
Mori K, Kurihara T, Jiang X, Ikeda S-i, Ishida A, Torii H, Tsubota K. Effects of Hyperoxia on the Refraction in Murine Neonatal and Adult Models. International Journal of Molecular Sciences. 2019; 20(23):6014. https://doi.org/10.3390/ijms20236014
Chicago/Turabian StyleMori, Kiwako, Toshihide Kurihara, Xiaoyan Jiang, Shin-ichi Ikeda, Ayako Ishida, Hidemasa Torii, and Kazuo Tsubota. 2019. "Effects of Hyperoxia on the Refraction in Murine Neonatal and Adult Models" International Journal of Molecular Sciences 20, no. 23: 6014. https://doi.org/10.3390/ijms20236014