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Open AccessReview

Oxidative Stress and Microglial Response in Retinitis Pigmentosa

1
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
2
Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(19), 7170; https://doi.org/10.3390/ijms21197170
Received: 12 September 2020 / Accepted: 27 September 2020 / Published: 28 September 2020
(This article belongs to the Special Issue Molecular Research on Stress Response and Ocular Homeostasis)
An imbalance between the production of reactive oxygen species (ROS) and anti-oxidant capacity results in oxidative injury to cellular components and molecules, which in turn disturbs the homeostasis of cells and organs. Although retinitis pigmentosa (RP) is a hereditary disease, non-genetic biological factors including oxidative stress also modulate or contribute to the disease progression. In animal models of RP, the degenerating retina exhibits marked oxidative damage in the nucleic acids, proteins, and lipids, and anti-oxidant treatments substantially suppress photoreceptor cell death and microgliosis. Although the mechanisms by which oxidative stress mediates retinal degeneration have not been fully elucidated, our group has shown that oxidative DNA damage and its defense system are key regulators of microglial activation and photoreceptor degeneration in RP. In this review, we summarize the current evidence regarding oxidative stress in animal models and patients with RP. The clinical efficacy of anti-oxidant treatments for RP has not been fully established. Nevertheless, elucidating key biological processes that underlie oxidative damage in RP will be pivotal to understanding the pathology and developing a potent anti-oxidant strategy that targets specific cell types or molecules under oxidative stress. View Full-Text
Keywords: retinitis pigmentosa; oxidative stress; microglia; oxidative DNA damage retinitis pigmentosa; oxidative stress; microglia; oxidative DNA damage
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MDPI and ACS Style

Murakami, Y.; Nakabeppu, Y.; Sonoda, K.-H. Oxidative Stress and Microglial Response in Retinitis Pigmentosa. Int. J. Mol. Sci. 2020, 21, 7170. https://doi.org/10.3390/ijms21197170

AMA Style

Murakami Y, Nakabeppu Y, Sonoda K-H. Oxidative Stress and Microglial Response in Retinitis Pigmentosa. International Journal of Molecular Sciences. 2020; 21(19):7170. https://doi.org/10.3390/ijms21197170

Chicago/Turabian Style

Murakami, Yusuke; Nakabeppu, Yusaku; Sonoda, Koh-Hei. 2020. "Oxidative Stress and Microglial Response in Retinitis Pigmentosa" Int. J. Mol. Sci. 21, no. 19: 7170. https://doi.org/10.3390/ijms21197170

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