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Novel Programmed Cell Death as Therapeutic Targets in Age-Related Macular Degeneration?

1
Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
2
State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(19), 7279; https://doi.org/10.3390/ijms21197279
Received: 14 September 2020 / Revised: 29 September 2020 / Accepted: 29 September 2020 / Published: 1 October 2020
(This article belongs to the Special Issue Molecular Research on Stress Response and Ocular Homeostasis)
Age-related macular degeneration (AMD) is a leading cause of severe visual loss among the elderly. AMD patients are tormented by progressive central blurring/loss of vision and have limited therapeutic options to date. Drusen accumulation causing retinal pigment epithelial (RPE) cell damage is the hallmark of AMD pathogenesis, in which oxidative stress and inflammation are the well-known molecular mechanisms. However, the underlying mechanisms of how RPE responds when exposed to drusen are still poorly understood. Programmed cell death (PCD) plays an important role in cellular responses to stress and the regulation of homeostasis and diseases. Apart from the classical apoptosis, recent studies also discovered novel PCD pathways such as pyroptosis, necroptosis, and ferroptosis, which may contribute to RPE cell death in AMD. This evidence may yield new treatment targets for AMD. In this review, we summarized and analyzed recent advances on the association between novel PCD and AMD, proposing PCD’s role as a therapeutic new target for future AMD treatment. View Full-Text
Keywords: retina; vision; ocular stress; cell damage; homeostasis retina; vision; ocular stress; cell damage; homeostasis
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MDPI and ACS Style

Yang, M.; So, K.-F.; Lam, W.C.; Lo, A.C.Y. Novel Programmed Cell Death as Therapeutic Targets in Age-Related Macular Degeneration? Int. J. Mol. Sci. 2020, 21, 7279. https://doi.org/10.3390/ijms21197279

AMA Style

Yang M, So K-F, Lam WC, Lo ACY. Novel Programmed Cell Death as Therapeutic Targets in Age-Related Macular Degeneration? International Journal of Molecular Sciences. 2020; 21(19):7279. https://doi.org/10.3390/ijms21197279

Chicago/Turabian Style

Yang, Ming; So, Kwok-Fai; Lam, Wai C.; Lo, Amy C.Y. 2020. "Novel Programmed Cell Death as Therapeutic Targets in Age-Related Macular Degeneration?" Int. J. Mol. Sci. 21, no. 19: 7279. https://doi.org/10.3390/ijms21197279

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