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Special Issue "Novel Therapeutic Strategies in Multiple Myeloma"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (28 September 2018).
Despite recent advances in Multiple Myeloma (MM) treatment schemes, MM remains largely incurable. One of the major issues is the occurrence of drug resistance (DR) against most standard-of-care drugs. This DR can be either intrinsic or extrinsically induced by the bone marrow (BM) microenvironment. Intrinsic DR occurs through adaptive mutations and/or genetic alterations. Extrinsically, the BM environment protects MM cells through a plethora of mechanisms, including cytokines, adhesion-mediated pathways and small extracellular vesicles, termed exosomes. These exosomes can transfer information from the BM stromal compartment to MM cells and vice versa, leading to proliferation of the MM clone and DR. Moreover, BM can establish a metabolic “symbiosis” with the tumor cells, whereby there is an exchange of necessary metabolites, needed to sustain MM growth within this hypoxic milieu. In this Special Issue, we welcome contributions concerning all manner of novel therapeutic strategies to combat DR, either finding novel targets, unravelling the role of the (epi)genome or focusing on BM-related DR. Both fundamental and translational work is encouraged, including exosome-related research, drug resistance studies, metabolomics studies, RNA sequencing, CHIP sequencing and identification of new therapeutic targets.
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Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- cell–cell interactions
- NKT cells
- signaling pathways
- 5TMM murine model