Next Article in Journal
Biodegradable and Toughened Composite of Poly(Propylene Carbonate)/Thermoplastic Polyurethane (PPC/TPU): Effect of Hydrogen Bonding
Next Article in Special Issue
Future in the Past: Azorella glabra Wedd. as a Source of New Natural Compounds with Antiproliferative and Cytotoxic Activity on Multiple Myeloma Cells
Previous Article in Journal
A Current Overview of the Biological and Cellular Effects of Nanosilver
Previous Article in Special Issue
Inhibition of HIF1α-Dependent Upregulation of Phospho-l-Plastin Resensitizes Multiple Myeloma Cells to Frontline Therapy
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2018, 19(7), 2031;

New Insights in Anti-Angiogenesis in Multiple Myeloma

Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari 70124, Italy
Department of Biomedical Sciences, and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari 70124, Italy
Authors to whom correspondence should be addressed.
Received: 19 June 2018 / Revised: 8 July 2018 / Accepted: 10 July 2018 / Published: 12 July 2018
(This article belongs to the Special Issue Novel Therapeutic Strategies in Multiple Myeloma)
Full-Text   |   PDF [243 KB, uploaded 12 July 2018]   |  


Angiogenesis is a constant hallmark of multiple myeloma (MM) progression and involves direct production of angiogenic cytokines by plasma cells and their induction within the bone marrow microenvironment. This article summarizes the more recent literature data concerning the employment of anti-angiogenic therapeutic agents actually used in preclinical models and clinical settings for the treatment of multiple myeloma. View Full-Text
Keywords: angiogenesis; anti-angiogenesis; multiple myeloma; tumor growth angiogenesis; anti-angiogenesis; multiple myeloma; tumor growth

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Ribatti, D.; Vacca, A. New Insights in Anti-Angiogenesis in Multiple Myeloma. Int. J. Mol. Sci. 2018, 19, 2031.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top