Special Issue "Intrinsically Disordered Proteins (IDPs): From Physical Chemistry to Pathogenic Mechanisms"
Deadline for manuscript submissions: closed (30 September 2020).
Interests: intrinsically disordered proteins; folding copuled to binding; protein-protein interactions; structural transitions; paramyxoviruses
Special Issues and Collections in MDPI journals
Intrinsically disordered proteins (IDPs) represent ~50% of the human proteome and are implicated in major human diseases, such as cancer, neurodegeneration, and viral infections, emerging as potential targets for therapeutic approaches. In spite of the increasing interest attracted by IDPs in the last decades, the mechanistic relationships between structural disorder and biological function remain a major challenge. Moreover, IDP structural characterization requires description of dynamic and heterogeneous molecular ensembles and their rearrangements in response to environmental conditions. This Special Issue will highlight the link between the peculiar physicochemical properties of these polymers, their interactions, and their role under physiological and pathological conditions. Advanced biophysical methods for IDP structural investigation will also be discussed. Most of the papers derive from contributions to the International Summer School on “Intrinsically disordered proteins (IDPs)—From Physical Chemistry to Pathogenic Mechanisms” held in Como, Italy, in September 2019.
Topics include, without being limited to:: IDP identification, classification and characterization, liquid–liquid phase transitions, membrane-less organelles, conformational ensembles, molecular recognition, fuzzy complexes, protein networks, cancer, neurodegeneration, virus regulation, enzymatic IDPs, biophysical and mass spectrometry techniques, -omics approaches, disorder and aggregation prediction, computational modeling.
Prof. Stefania Brocca
Dr. Rita Grandori
Prof. Dr. Sonia Longhi
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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