Topic Editors

Department of Biochemical Sciences, Sapienza University of Rome, 00185 Rome, Italy
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
Architecture and Function of Biological Macromolecules (AFMB), UMR 7257 CNRS & Aix-Marseille University, 13288 Marseille, France

Function, Regulation, and Dysfunction of Intrinsically Disordered Proteins

Abstract submission deadline
closed (31 July 2021)
Manuscript submission deadline
closed (20 August 2021)
Viewed by
1457

Topic Information

Dear Colleagues,

It has become acknowledged that a significant portion of proteins encoded in eukaryotic and prokaryotic genomes feature a partial or total degree of structural disorder. Disordered regions can regulate the biological activity of protein molecules, such as the propensity to generate molecular complexity, including the regulation of phase separations. The involvement of intrinsically disordered proteins in fundamental biological processes, including cellular signaling, protein translation, and transcriptional regulation, is increasingly reported to be crucial in functional and pathological mechanisms. The remarkable ability of these molecules to establish macromolecular interactions with multiple biomolecular partners is likely promoted by their inherent flexibility and ability to adapt their shape. While the functional role of IDPs is attracting an increasing research focus, understanding the underlying structural and mechanistic principles of their biological activity remains a crucial research challenge. The role of kinetic versus thermodynamic control is the key to understand the way by which these elusive systems are regulated to solve their intriguing biological functions.

Prof. Dr. Stefano Gianni
Dr. Giuliana Fusco
Dr. Sonia Longhi
Topic Editors

Keywords

  • intrinsically disordered proteins
  • post-translational modifications
  • phase separation
  • structural and functional dynamics
  • binding promiscuity and fuzzy complexes
  • molten globular states
  • kinetic vs thermodynamic control
  • conformational selection vs induced fit

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Life
life
3.2 4.3 2011 18 Days CHF 2600
International Journal of Molecular Sciences
ijms
4.9 8.1 2000 18.1 Days CHF 2900

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