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Special Issue "Genome Editing"
Deadline for manuscript submissions: closed (30 April 2016).
Prof. Dr. Izuho Hatada Website E-Mail
Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371-8512, Japan
Interests: genome editing; epigenome editing; epigenetics; genomics; microRNA; genomic imprinting; obesity
Conventional gene targeting methods using homologous recombination are generally used for making knockout mice. However, the efficiency of this technology is not high. Therefore, the method requires embryonic stem cells. A recent breakthrough is the development of site-specific endonucleases for selective genome cleavage. Because of this method’s high efficiency, these endonucleases make it possible to direct gene targeting using fertilized eggs. These enzymes include zinc-finger nucleases (ZFN), transcription activator-like effector nucleases (TALEN), and Cas9 nucleases. The technology using these nucleases is called “genome editing.” By using these technologies, we can make knockout organisms, including for most animals and plants, which cannot be created via conventional methods. Through combination with other technologies, genome editing can generate many new technologies, such as epigenome editing, live imaging, and genome-wide screening. The field of genome editing is growing at a surprisingly rapid rate and has had a great impact on basic science, clinical applications, and breeding technologies. The main purpose of this Special Issue is to provide an open-source sharing of significant works in the field of genome editing, so as to archive new technological developments and applications.
Prof. Dr. Izuho Hatada
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- genome editing
- target design
- homology-directed repair (HDR)
- epigenome editing
- live imaging
- genome-wide screening
- pluripotent stem cells
- iPS cells
- gene therapy