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Article

Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and -9

by
Heiko Schulz
1,
Christina Kuhn
1,
Simone Hofmann
1,
Doris Mayr
2,
Sven Mahner
1,
Udo Jeschke
1,* and
Elisa Schmoeckel
2
1
LMU Munich, University Hospital, Department of Obstetrics and Gynecology, Maistrasse 11, 80337 Munich, Germany
2
LMU Munich, Department of Pathology, Ludwig Maximilians University of Munich, Thalkirchner Str. 142, 80337 Munich, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(1), 323; https://doi.org/10.3390/ijms19010323
Submission received: 28 November 2017 / Revised: 16 January 2018 / Accepted: 18 January 2018 / Published: 22 January 2018
(This article belongs to the Special Issue Galectins in Cancer and Translational Medicine)
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Abstract

The evaluation of new prognostic factors that can be targeted in ovarian cancer diagnosis and therapy is of the utmost importance. Galectins are a family of carbohydrate binding proteins with various implications in cancer biology. In this study, the presence of galectin (Gal)-8 and -9 was investigated in 156 ovarian cancer samples using immunohistochemistry (IHC). Staining was evaluated using semi-quantitative immunoreactivity (IR) scores and correlated to clinical and pathological data. Different types of galectin expression were compared with respect to disease-free survival (DFS) and overall survival (OS). Gal-8 served as a new positive prognostic factor for the OS and DFS of ovarian cancer patients. Gal-9 expression determined the DFS and OS of ovarian cancer patients in two opposing ways—moderate Gal-9 expression was correlated with a reduced outcome as compared to Gal-9 negative cases, while patients with high Gal-9 expression showed the best outcome.
Keywords: galectin-8; galectin-9; immunochemistry; ovarian cancer; prognostic factor; disease-free survival; overall survival galectin-8; galectin-9; immunochemistry; ovarian cancer; prognostic factor; disease-free survival; overall survival
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MDPI and ACS Style

Schulz, H.; Kuhn, C.; Hofmann, S.; Mayr, D.; Mahner, S.; Jeschke, U.; Schmoeckel, E. Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and -9. Int. J. Mol. Sci. 2018, 19, 323. https://doi.org/10.3390/ijms19010323

AMA Style

Schulz H, Kuhn C, Hofmann S, Mayr D, Mahner S, Jeschke U, Schmoeckel E. Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and -9. International Journal of Molecular Sciences. 2018; 19(1):323. https://doi.org/10.3390/ijms19010323

Chicago/Turabian Style

Schulz, Heiko, Christina Kuhn, Simone Hofmann, Doris Mayr, Sven Mahner, Udo Jeschke, and Elisa Schmoeckel. 2018. "Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and -9" International Journal of Molecular Sciences 19, no. 1: 323. https://doi.org/10.3390/ijms19010323

APA Style

Schulz, H., Kuhn, C., Hofmann, S., Mayr, D., Mahner, S., Jeschke, U., & Schmoeckel, E. (2018). Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and -9. International Journal of Molecular Sciences, 19(1), 323. https://doi.org/10.3390/ijms19010323

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