Special Issue "Biodegradability of Materials in Biomedical Applications 2011"
Deadline for manuscript submissions: closed (31 May 2011)
Prof. Dr. Showan N. Nazhat
Department of Mining and Materials Engineering, McGill University, Montreal, Canada
New generation biomaterials should be able to stimulate specific cellular responses at the molecular level, moving from the concept of inertness to one of bioactivity, e.g. positive interaction at the biomaterial-tissue interface. In many cases the body needs only the temporary presence of a device or implant, in which case fully or partially biodegradable materials are better alternatives than biostable materials. The ideal biodegradable material – polymer, ceramic, metal or composite - should be biocompatible, provide adequate initial mechanical fixation, controllably degradable, and should ultimately be replaced by the regenerated tissue.
A wide range of biodegradable materials is being continuously investigated for biomedical applications, which include traditional and advanced biodegradable polymers, bioceramics and composites as well as a small group of metals and alloys based on magnesium.
Typical applications and research areas of biodegradable polymers include surgery sutures, wound dressing, antibacterial coatings, fixation devices, tissue engineering scaffolds as well as drug and cell delivery platforms. Current research focuses also on the development of biodegradable composites combining synthetic or natural biodegradable polymers and bioactive inorganic fillers, e.g. bioactive glasses and calcium phosphate ceramics, which mimic the structural characteristics of the natural extracellular matrix. Magnesium alloys are promising candidates for several structural biomedical applications due to their degradation ability combined with appropriate mechanical properties as well as good biocompatibility and are being proposed as cardiovascular stents, bone fixation devices and porous bone repair materials.
The present combined special issue in IJMS/Materials will include papers authored by researchers around the world reporting on cutting-edge results in the broad field of biodegradable materials for biomedical applications.
Prof. S. N. Nazhat
Prof. A. R. Boccaccini
- biodegradable polymers
- magnesium alloys
- bioactive glasses
- calcium phosphates
- tissue engineering
- drug delivery
- wound dressing
- degradable stents