Special Issue "Amyotrophic Lateral Sclerosis: Highlights of Its Complexity"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 April 2019).
Amyotrophic Lateral Sclerosis (ALS) is the most common motor neuron disease of the adult, characterized by progressive skeletal muscle paralysis and premature death due to respiratory failure. There is still no effective therapy to prevent the development and progression of this devastating disease, for this reason ALS is currently an area of great interest in research. In the last 25 years there have been enormous advancements in the identification of genetic risk factors associated with ALS susceptibility, highlighting the genetic and phenotypic heterogeneity of this disease. Thanks to these genetic discoveries and the development of new experimental models of the disease, it has become clear that ALS results from a complex phenomenon involving multifactorial, multicellular and multisystem mechanisms, ultimately leading to the progressive vulnerability and death of the motor neurons.
This Special Issue on ALS aims to review the latest advance in ALS research that include: 1) the new results from the large-scale genome wide association studies (GWAS) and next-generation sequencing; 2) the development of new in vitro and in vivo experimental models tailored to approach the genetic heterogeneity of the disease; 3) the identification of biomarkers that allows to predict the disease progression and to stratify ALS patients for clinical trials; 4) the study of interaction between different cell types in the axis that goes from the central nervous system to the muscle including other components like the immune system; and 5) the examination of strategies that potentially lead to disease-modifying treatments.
Dr. Caterina Bendotti
Dr. Nicola Ticozzi
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- Motor neuron disease
- Neuromuscular disease
- Glial cells
- Immune system
- RNA metabolism
- Protein aggregation
- Axonal dysfunction
- Gene therapy
- Cell therapy