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Risk Factors and Emerging Therapies in Amyotrophic Lateral Sclerosis
Review

Are Circulating Cytokines Reliable Biomarkers for Amyotrophic Lateral Sclerosis?

Laboratory of Genetics and Biochemistry (LAGENBIO), Faculty of Veterinary-IIS Aragón, IA2-CITA, CIBERNED, University of Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain
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Int. J. Mol. Sci. 2019, 20(11), 2759; https://doi.org/10.3390/ijms20112759
Received: 30 April 2019 / Revised: 30 May 2019 / Accepted: 3 June 2019 / Published: 5 June 2019
(This article belongs to the Special Issue Amyotrophic Lateral Sclerosis: Highlights of Its Complexity)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that has no effective treatment. The lack of any specific biomarker that can help in the diagnosis or prognosis of ALS has made the identification of biomarkers an urgent challenge. Multiple panels have shown alterations in levels of numerous cytokines in ALS, supporting the contribution of neuroinflammation to the progressive motor neuron loss. However, none of them is fully sensitive and specific enough to become a universal biomarker for ALS. This review gathers the numerous circulating cytokines that have been found dysregulated in both ALS animal models and patients. Particularly, it highlights the opposing results found in the literature to date, and points out another potential application of inflammatory cytokines as therapeutic targets. View Full-Text
Keywords: cytokines; biomarkers; amyotrophic lateral sclerosis; blood; plasma; serum; cerebrospinal fluid; diagnosis; prognosis; inflammation cytokines; biomarkers; amyotrophic lateral sclerosis; blood; plasma; serum; cerebrospinal fluid; diagnosis; prognosis; inflammation
MDPI and ACS Style

Moreno-Martinez, L.; Calvo, A.C.; Muñoz, M.J.; Osta, R. Are Circulating Cytokines Reliable Biomarkers for Amyotrophic Lateral Sclerosis? Int. J. Mol. Sci. 2019, 20, 2759. https://doi.org/10.3390/ijms20112759

AMA Style

Moreno-Martinez L, Calvo AC, Muñoz MJ, Osta R. Are Circulating Cytokines Reliable Biomarkers for Amyotrophic Lateral Sclerosis? International Journal of Molecular Sciences. 2019; 20(11):2759. https://doi.org/10.3390/ijms20112759

Chicago/Turabian Style

Moreno-Martinez, Laura, Ana C. Calvo, María J. Muñoz, and Rosario Osta. 2019. "Are Circulating Cytokines Reliable Biomarkers for Amyotrophic Lateral Sclerosis?" International Journal of Molecular Sciences 20, no. 11: 2759. https://doi.org/10.3390/ijms20112759

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