Therapy and Prevention of Atopic Dermatitis and Psoriasis 2020

Dear Colleagues,

The skin is the outermost part of the body and is an area where various external and internal stimuli interact. Complex interface reactions are necessary for maintaining the homeostasis of the epidermal and dermal compartments, and imbalance results in numerous inflammatory disorders, such as psoriasis and atopic dermatitis. The excellent therapeutic success of biological treatments stress the pathogenetic importance of the TNF-α/IL-23/IL-17 axis for psoriasis and IL-4/IL-13 signals for atopic dermatitis. Common external stimuli include ultraviolet rays, chemicals, allergens, and environmental pollutants. Some of these agents modulate psoriatic and atopic inflammation by activating the oxidative aryl hydrocarbon receptor as well as the antioxidative NRF2 transcription factors. Various cytochemokines involved in Th17 and Th2 deviation are also involved in psoriatic and atopic inflammation, respectively, by facilitating the differentiation and recruitent of pathogenic dendritic cells, T-cells, and innate lymphoid cells.

In this Special Issue of IJMS, we will publish cutting-edge information regarding skin inflammation, therapy, and prevention, especially related to psoriatic and atopic inflammation. We warmly welcome submissions, including original papers and reviews.

Prof. Dr. Masutaka Furue
Assoc. Prof. Dr. Takeshi Nakahara
Assoc. Prof. Dr. Gaku Tsuji
Guest Editor

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