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Mechanisms Regulating Osteoclastogenesis in Physiological and Pathological Conditions

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (31 May 2018)

Special Issue Editors

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Guest Editor
Department of Biosciences, Biotechnologies, and Environment, University of Bari, Piazza Giulio Cesare, 11, 70124 Bari, Italy
Interests: osteoimmunology; osteoclast; osteoblast; bone remodeling; bone diseases; cardiovascular disease
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Guest Editor
Department of Clinical and Experimental Medicine, University of Foggia Medical School, Via L. Pinto, 71122 Foggia, Italy
Interests: stem cells; osteoclast; osteoblast; bone remodeling; tissue regeneration
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Guest Editor
Department of Biomedical Sciences and Human Oncology, Section of Pediatrics, University of Bari Aldo Moro, 70121 Bari, Italy
Interests: bone health; nutrigenomics; nutraceuticals; polyphenols; extra virgin olive oil
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Special Issue Information

Dear colleagues,

Bone remodeling is a tightly regulated process involving the interplay among osteoclasts, osteoblasts, and osteocytes. Osteoclasts are the bone resorbing cells arising from the fusion of monocyte/macrophage precursors. Osteoclastogenesis is primarily supported by osteoblasts but also by other cells of the bone marrow microenvironment, such as immune cells, adipocytes, and endothelial cells. Osteoclastogenesis is a finely controlled process, and its deregulation is related to different bone diseases; thus, the deepening of the mechanisms regulating osteoclast formation can be useful for identifying new pharmacological targets.

The Editors encourage submissions of full-review or original research papers, and perspectives on the biological, functional, and mechanistic question(s) being addressed.

Prof. Giacomina Brunetti
Prof. Giorgio Mori
Prof. Maria Felicia Faienza
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • osteoclasts
  • osteoimmunology
  • T cells
  • B cells
  • bone marrow microenvironment
  • osteoblasts
  • growth factors
  • cytokines

Published Papers

There is no accepted submissions to this special issue at this moment.
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