Ovary and Testis: Molecular Biological Insights

Dear Colleagues,

This Special Issue, “Ovary and testis: Molecular Biological Insights”, will cover a selection of recent research and current review articles in the field. This Special Issue is devoted not only to research directly related to the cryopreservation of cells, but also to the study of the characteristics of spermatogenesis and oogenesis theoretically associated with the cell cryo-resistance. The cryopreservation of ovarian and testicular tissues leads to cell damage. Intracellular and extracellular ice-crystal formation and osmotic damage of cells can further deteriorate their viability. The production of reactive oxygen species leads to an increase in lipid peroxidation after the cryopreservation of tissue, which is associated with a loss of viability. Cryopreservation also leads to diminished antioxidant defense activity during cooling and (or) structural damage to the cytoskeleton and (or) antioxidant enzymes. It can also lead to chromatin damage, which is extremely important because chromatin abnormalities have repercussions on cell quality. Additionally, cell DNA damage is strongly correlated with the mutagenic effects of cryopreservation. The study of such cryo-changes using molecular biological methods can aid the development of more efficient cryopreservation technologies. It is also known that the cryo-biological properties of cells can change during the process of oogenesis and spermatogenesis.  

Dr. Pradeep Kumar (drpradeepkrvet@gmail.com, Central Institute for Research of Buffaloes, Hisar, India) and Dr. Wensheng Liu (liuws@gdszjk.org.cn, Center of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, China), whose central area of research interest are mammalian testis and ovarian tissues are serving as co-Guest Editor and will assist Dr. (SU) Volodimir Isachenko and Prof. Dr. med. Frank Nawroth in managing this Issue.

Dr. Volodimir Isachenko
Prof. Dr. Frank Nawroth
Guest Editors

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