Recent Advances in Gastrointestinal Cancer 2.0

Dear Colleagues,

Gastrointestinal cancer is the most common human malignancy, with colorectal and gastric cancer accounting for the third and fifth highest global incidences, respectively. Despite the use of new and innovative chemotherapeutic agents and combinational treatment strategies, including chemotherapy, surgery, radiotherapy and targeted therapies, modern medicine still lacks a fully effective therapy approach. In addition, survival rates remain notably low for patients with advanced disease. A better knowledge of the molecular mechanisms that influence cancer progression and the development of optimal therapeutic strategies for gastrointestinal cancer malignancies is urgently needed. Alongside the need for utilizing existing knowledge in the field of development and synthesizing new, potential chemotherapeutic agents characterized by an appropriate effectiveness of action on gastrointestinal cancer cells, it is also important to emphasize prevention, which may involve, for example, proper nutrition. Numerous studies show that natural plant-derived compounds may contribute to prevention and support the treatment of gastrointestinal cancer and other chronic diseases. The anticancer potential of compounds is often related to changes in the expression of genes that are implicated in cell cycle arrest and apoptotic death.

This Special Issue is supervised by Dr. Aneta Koronowicz and assisted by our Topical Advisory Panel Member Dr. Ewelina Piasna-Słupecka (University of Agriculture in Krakow). In this Special Issue, we will discuss recent advances and future directions of therapy for malignant tumors of the gastrointestinal system, and also describe innovative chemotherapeutic agents. In addition, we will discuss the biological properties of natural products and new and classical dietary bioactive compounds which may reduce the risk for gastrointestinal cancer diseases in the future.

More published papers can be found in the closed Special Issue “Recent Advances in Gastrointestinal Cancer”.

Dr. Aneta Koronowicz
Guest Editor

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• gastrointestinal cancer
• chemotherapeutic agents
• innovative therapies
• human nutrition
• nutrigenomics
• nutrition and immunity
• epigenetics
• cytotoxicity
• apoptosis