Next Article in Journal
Rapid Diminution in the Level and Activity of DNA-Dependent Protein Kinase in Cancer Cells by a Reactive Nitro-Benzoxadiazole Compound
Next Article in Special Issue
Role of Mitochondrial DNA Copy Number Alteration in Human Renal Cell Carcinoma
Previous Article in Journal
Hairpin RNA Targeting Multiple Viral Genes Confers Strong Resistance to Rice Black-Streaked Dwarf Virus
Previous Article in Special Issue
The Role of Chemokines in Promoting Colorectal Cancer Invasion/Metastasis
Open AccessReview

Cell and Signal Components of the Microenvironment of Bone Metastasis Are Affected by Hypoxia

1
Dipartimento di Scienze Biomediche per la Salute, Molecular Pathology Laboratory, Università degli Studi di Milano, 20133 Milano, Italy
2
Istituto Ortopedico Galeazzi, Scientific Institute for Research, Hospitalization and Health Care (IRCCS), 20161 Milano, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Li Yang
Int. J. Mol. Sci. 2016, 17(5), 706; https://doi.org/10.3390/ijms17050706
Received: 23 March 2016 / Revised: 28 April 2016 / Accepted: 3 May 2016 / Published: 11 May 2016
(This article belongs to the Special Issue Tumor Microenvironment and Metabolism)
Bone metastatic cells release bone microenvironment proteins, such as the matricellular protein SPARC (secreted protein acidic and rich in cysteine), and share a cell signaling typical of the bone metabolism controlled by Runx2. The megakaryocytes in the bone marrow engrafted by the metastases seem to be one of the principal microenvironment sources of the biological stimuli, implicated in the formation of an osteoblastic niche, and affecting metastasis phenotype and colonization. Educated platelets in the circulation might derive from megakaryocytes in bone metastasis. The evaluation of predictive markers in the circulating platelets might be useful for the stratification of patients for therapeutic purposes. The hypoxic environment in bone metastasis is one of the key regulators of the network of the biological soluble and structural components of the matrix. In bone metastatic cells under hypoxia, similar patterns of Runx2 and SPARC are observed, both showing downregulation. Conversely, hypoxia induces Endothelin 1, which upregulates SPARC, and these biological stimuli may be considered prognostic markers of bone metastasis in breast carcinoma patients. View Full-Text
Keywords: bone metastasis; hypoxic microenvironment; megakaryocytes; secreted protein acidic and rich in cysteine (SPARC); HIF-1; hepatocyte growth factor bone metastasis; hypoxic microenvironment; megakaryocytes; secreted protein acidic and rich in cysteine (SPARC); HIF-1; hepatocyte growth factor
Show Figures

Graphical abstract

MDPI and ACS Style

Bendinelli, P.; Maroni, P.; Matteucci, E.; Desiderio, M.A. Cell and Signal Components of the Microenvironment of Bone Metastasis Are Affected by Hypoxia. Int. J. Mol. Sci. 2016, 17, 706. https://doi.org/10.3390/ijms17050706

AMA Style

Bendinelli P, Maroni P, Matteucci E, Desiderio MA. Cell and Signal Components of the Microenvironment of Bone Metastasis Are Affected by Hypoxia. International Journal of Molecular Sciences. 2016; 17(5):706. https://doi.org/10.3390/ijms17050706

Chicago/Turabian Style

Bendinelli, Paola; Maroni, Paola; Matteucci, Emanuela; Desiderio, Maria A. 2016. "Cell and Signal Components of the Microenvironment of Bone Metastasis Are Affected by Hypoxia" Int. J. Mol. Sci. 17, no. 5: 706. https://doi.org/10.3390/ijms17050706

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop