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Open AccessReview

Lysyl Oxidase and the Tumor Microenvironment

by 1,2,3,4, 5,6,* and 7,*
1
Tissue Bank, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan
2
Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan
3
Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan 33305, Taiwan
4
Liver Research Center, Chang Gung Memorial Hospital, Taoyuan 33303, Taiwan
5
School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan
6
Nutrition Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan
7
Department of Dental Hygiene, College of Health Care, China Medical University, Taichung 40402, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Li Yang
Int. J. Mol. Sci. 2017, 18(1), 62; https://doi.org/10.3390/ijms18010062
Received: 26 November 2016 / Revised: 20 December 2016 / Accepted: 23 December 2016 / Published: 29 December 2016
(This article belongs to the Special Issue Tumor Microenvironment and Metabolism)
The lysyl oxidase (LOX) family of oxidases contains a group of extracellular copper-dependent enzymes that catalyze the cross-linking of collagen and elastin by oxidation, thus maintaining the rigidity and structural stability of the extracellular matrix (ECM). Aberrant expression or activation of LOX alters the cellular microenvironment, leading to many diseases, including atherosclerosis, tissue fibrosis, and cancer. Recently, a number of studies have shown that LOX is overexpressed in most cancers and that it is involved in the regulation of tumor progression and metastasis. In contrast, a few reports have also indicated the tumor-suppressing role of LOX. In this short review, we discuss recent research on the correlations between LOX and cancer. Further, the role of LOX in tumor microenvironment remodeling, tumorigenesis, and metastasis and the underlying mechanisms have also been elucidated. View Full-Text
Keywords: lysyl oxidase; microenvironment; tumor progression; tumor suppressor; metastasis lysyl oxidase; microenvironment; tumor progression; tumor suppressor; metastasis
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MDPI and ACS Style

Wang, T.-H.; Hsia, S.-M.; Shieh, T.-M. Lysyl Oxidase and the Tumor Microenvironment. Int. J. Mol. Sci. 2017, 18, 62. https://doi.org/10.3390/ijms18010062

AMA Style

Wang T-H, Hsia S-M, Shieh T-M. Lysyl Oxidase and the Tumor Microenvironment. International Journal of Molecular Sciences. 2017; 18(1):62. https://doi.org/10.3390/ijms18010062

Chicago/Turabian Style

Wang, Tong-Hong; Hsia, Shih-Min; Shieh, Tzong-Ming. 2017. "Lysyl Oxidase and the Tumor Microenvironment" Int. J. Mol. Sci. 18, no. 1: 62. https://doi.org/10.3390/ijms18010062

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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