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IJMS
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Molecular Biology of Senescence and Anti-Aging Strategies
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Molecular Biology of Senescence and Anti-Aging Strategies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 2117

Special Issue Editors

Dr. Nicola Alessio

E-Mail Website
Guest Editor
Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Interests: stem cells; cell therapy; secretome; extracellular-vesicle; exosomes; differentiation; inflammation; diseases
Special Issues, Collections and Topics in MDPI journals
Dr. James T. Arnone

E-Mail Website
Guest Editor
Department of Biological and Environmental Sciences, Le Moyne College, Syracuse, NY 13214, USA
Interests: gene expression; genetics; genomics; aging; biochemistry; molecular biology; fungi
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Senescence, a natural aging process, is a complex interplay of genetic, epigenetic, and environmental factors. To counteract its effects, researchers are exploring innovative anti-aging strategies. Genetic interventions, including the manipulation of longevity-associated genes, show promise in enhancing cellular repair mechanisms. Caloric restriction and nutrient sensing, proven to extend lifespan in various organisms, are under scrutiny for their impact on aging pathways. Senolytic and senomorphic drugs aim to eliminate or modify senescent cells, potentially delaying the progression of age-related diseases. Telomere maintenance strategies, focused on preserving chromosomal integrity, also offer avenues for combating cellular senescence and promoting healthier aging.

IJMS sets up this Special Issue, focusing on the current understanding and future research directions regarding the molecular mechanisms of senescence and anti-aging strategies. We welcome original research articles and review articles relating to this hot topic.

Dr. Nicola Alessio
Dr. James T. Arnone
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cellular senescence
  • aging
  • delaying senescence
  • aging-associated diseases

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Published Papers (1 paper)

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Research

14 pages, 2063 KiB  
Article
Effects of PACAP Deficiency on Immune Dysfunction and Peyer’s Patch Integrity in Adult Mice
by Jason Sparks, Matyas Meggyes, Lilla Makszin, Viktoria Jehn, Hedvig Lugosi, Dora Reglodi and Laszlo Szereday
Int. J. Mol. Sci. 2024, 25(19), 10676; https://doi.org/10.3390/ijms251910676 - 3 Oct 2024
Viewed by 1539
Abstract
PACAP (pituitary adenylate cyclase activating polypeptide) is a widespread neuropeptide with cytoprotective and anti-inflammatory effects. It plays a role in innate and adaptive immunity, but data are limited about gut-associated lymphoid tissue. We aimed to reveal differences in Peyer’s patches between wild-type (WT) [...] Read more.
PACAP (pituitary adenylate cyclase activating polypeptide) is a widespread neuropeptide with cytoprotective and anti-inflammatory effects. It plays a role in innate and adaptive immunity, but data are limited about gut-associated lymphoid tissue. We aimed to reveal differences in Peyer’s patches between wild-type (WT) and PACAP-deficient (KO) mice. Peyer’s patch morphology from young (3-months-old) and aging (12–15-months-old) mice was examined, along with flow cytometry to assess immune cell populations, expression of checkpoint molecules (PD-1, PD-L1, TIM-3, Gal-9) and functional markers (CD69, granzyme B, perforin) in CD3+, CD4+, and CD8+ T cells. We found slight differences between aging, but not in young, WT, and KO mice. In WT mice, aging reduced CD8+ T cell numbers frequency and altered checkpoint molecule expression (higher TIM-3, granzyme B; lower Gal-9, CD69). CD4+ T cell frequency was higher with similar checkpoint alterations, indicating a regulatory shift. In PACAP KO mice, aging did not change cell population frequencies but led to higher TIM-3, granzyme B and lower PD-1, PD-L1, Gal-9, and CD69 expression in CD4+ and CD8+ T cells, with reduced overall T cell activity. Thus, PACAP deficiency impacts immune dysfunction by altering checkpoint molecules and T cell functionality, particularly in CD8+ T cells, suggesting complex immune responses by PACAP, highlighting its role in intestinal homeostasis and potential implications for inflammatory bowel diseases. Full article
(This article belongs to the Special Issue Molecular Biology of Senescence and Anti-Aging Strategies)
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