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Biology
Special Issues
10th Meeting—Stem Cell Research Italy
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10th Meeting—Stem Cell Research Italy

A special issue of Biology (ISSN 2079-7737).

Deadline for manuscript submissions: closed (31 January 2020) | Viewed by 7986

Special Issue Editors

Dr. Dario Siniscalco

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Guest Editor
Department of Experimental Medicine, University of Campania, 80138 Naples, Italy
Interests: autism; gene expression; cell biology; stem cells; apoptosis; neuroinflammation
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Umberto Galderisi

E-Mail Website
Guest Editor
Department of Experimental Medicine, Luigi Vanvitelli Campania University, 80138 Naples, Italy
Interests: stem cell; MUSE cells; cellular biology
Special Issues, Collections and Topics in MDPI journals
Dr. Nicola Alessio

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Guest Editor
University of Campania "Vanvitelli", 80138 Naples, Italy
Interests: cellular senescence; radiation therapy; stem cells; cell cycle
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The tenth meeting organized by Stem Cell Research Italy (SCR Italy) provides the state-of-the-art and the novel findings in stem cell research. Nowadays, stem cell therapy represents the great promise for the future of molecular and regenerative medicine. Indeed, several types of stem cells could be a real opportunity in order to provide a valid approach to cellular transplantation for human diseases. Furthermore, the meeting also provides recent insights on stem cell biology, action mechanisms, and functions, aspects that need to be clarified before using stem cells in clinical settings. Basic and pre-clinical research on stem cells and their application in in vivo models of diseases provide scientific evidence for future human applications. Special emphasis will also be due to the secretome and extrinsic signaling of the stem cells. All of these themes will be discussed in this meeting, and related papers will cover stem cell subtypes with their newest basic and applied research.

Dr. Dario Siniscalco
Prof. Umberto Galderisi
Dr. Nicola Alessio
Guest Editors

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Keywords

  • from basic to applied research with stem cells
  • stem cells and muscle diseases
  • stem cells and cancer
  • extrinsic signaling and stem cell functions

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Published Papers (2 papers)

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8 pages, 1749 KiB  
Communication
Unravelling Cellular Mechanisms of Stem Cell Senescence: An Aid from Natural Bioactive Molecules
by Sara Cruciani, Giuseppe Garroni, Giorgio Carlo Ginesu, Angela Fadda, Carlo Ventura and Margherita Maioli
Biology 2020, 9(3), 57; https://doi.org/10.3390/biology9030057 - 20 Mar 2020
Cited by 13 | Viewed by 3321
Abstract
Cellular senescence plays a role in the onset of age-related pathologies and in the loss of tissue homeostasis. Natural compounds of food or plants exert an important antioxidant activity, counteracting the formation of harmful free radicals. In the presence of an intense stressing [...] Read more.
Cellular senescence plays a role in the onset of age-related pathologies and in the loss of tissue homeostasis. Natural compounds of food or plants exert an important antioxidant activity, counteracting the formation of harmful free radicals. In the presence of an intense stressing event, cells activate specific responses to counteract senescence or cell death. In the present paper, we aimed at evaluating the levels of expression of specific markers of senescence, in order to demonstrate that extracts from Myrtus Communis L. can prevent premature senescence in ADSCs exposed to oxidative stress. Cells were cultured in the presence of Myrtus extracts for 12–24 and 48 h and then incubated with H2O2 to induce senescence. We then evaluated the expression of senescence-related markers p16, p19, p21, p53, TERT, c-Myc, and the senescence-associated β-Galactoidase activity. Our results showed that pre-treatment with Myrtus extracts protects cells from premature senescence, by regulating the cell cycle, and inducing the expression of TERT and c-Myc. These findings suggest a potential application of these natural compounds in the prevention and treatment of various diseases, counteracting premature senescence and preserving tissue functions. Full article
(This article belongs to the Special Issue 10th Meeting—Stem Cell Research Italy)
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16 pages, 260 KiB  
Conference Report
New Frontiers in Stem Cell Research and Translational Approaches
by Nicola Alessio, Dario Siniscalco, Gianfranco Peluso and Umberto Galderisi
Biology 2020, 9(1), 11; https://doi.org/10.3390/biology9010011 - 4 Jan 2020
Cited by 2 | Viewed by 3961
Abstract
Stem cell biology represents a challenging research area with a huge potential translational approach. This review focuses on the most recent findings on stem cell basics and clinics in several fields of research, as final outcome of the 10th conference held by Stem [...] Read more.
Stem cell biology represents a challenging research area with a huge potential translational approach. This review focuses on the most recent findings on stem cell basics and clinics in several fields of research, as final outcome of the 10th conference held by Stem Cell Research Italy (SCR Italy) in Naples, Italy in June 2019. Current state-of-the-art and novel findings on stem cell research are discussed, bringing together basic and applied research with the newest insights in stem cell therapy. Full article
(This article belongs to the Special Issue 10th Meeting—Stem Cell Research Italy)
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