Special Issue "Purinergic P2 Receptors: Structure and Function"
Deadline for manuscript submissions: 30 April 2020.
ATP (adenosine-5´-triphosphate) is a multifunctional intracellular molecule that serves as an energy source in all living cells. Much less is known about its role as an extracellular messenger or neurotransmitter. Extracellular ATP and its metabolic products acts on its plasma membrane receptors termed purinergic receptors, composed of two families: the ion-conducting P2X receptor channels and G protein-coupled P2Y receptors. By mediating depolarization, Ca2+ influx, and Ca2+ mobilization from intracellular stores, the extracellular nucleotide/P2 receptor system has numerous functions in excitable and nonexcitable cells. P2X and P2Y receptors have been documented in many physiological and pathological processes including inflammation, pain, and cancer and are potential therapeutic targets for treatment of these pathologies. This perspective is closely related to understanding the molecular physiology of these receptors that might be activated simultaneously if expressed in the same cell.
This issue aims to present the contemporary research on structural insights into the function of P2X and P2Y receptors, and their physiology and pharmacology. It may include original articles covering experimental reports on some particular receptor, technical development or novel screening technologies, as well as review papers relating to the subjects.
Dr. Hana Zemkova
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Extracellular ATP
- Purinergic signaling
- P2X receptor
- P2Y receptor
- ATP release
- Molecular structure
- Molecular pathway