Next Article in Journal
Facts about Fats: New Insights into the Role of Lipids in Metabolism, Disease and Therapy
Previous Article in Journal
An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy
Previous Article in Special Issue
Lithium Chloride Sensitivity in Yeast and Regulation of Translation
Open AccessReview

Ionizing Radiation and Translation Control: A Link to Radiation Hormesis?

1
Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada
2
Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada
3
Institut de Radioprotection et de Sureté Nucléaire (IRSN), PSE-SANTE, SESANE, LRTOX, 92262 Fontenay-aux-Roses Cedex, France
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(18), 6650; https://doi.org/10.3390/ijms21186650
Received: 7 August 2020 / Accepted: 4 September 2020 / Published: 11 September 2020
(This article belongs to the Special Issue Protein Synthesis and Disease)
Protein synthesis, or mRNA translation, is one of the most energy-consuming functions in cells. Translation of mRNA into proteins is thus highly regulated by and integrated with upstream and downstream signaling pathways, dependent on various transacting proteins and cis-acting elements within the substrate mRNAs. Under conditions of stress, such as exposure to ionizing radiation, regulatory mechanisms reprogram protein synthesis to translate mRNAs encoding proteins that ensure proper cellular responses. Interestingly, beneficial responses to low-dose radiation exposure, known as radiation hormesis, have been described in several models, but the molecular mechanisms behind this phenomenon are largely unknown. In this review, we explore how differences in cellular responses to high- vs. low-dose ionizing radiation are realized through the modulation of molecular pathways with a particular emphasis on the regulation of mRNA translation control. View Full-Text
Keywords: ionizing radiation; protein synthesis; mRNA translation; low doses; radiation hormesis ionizing radiation; protein synthesis; mRNA translation; low doses; radiation hormesis
Show Figures

Figure 1

MDPI and ACS Style

Kabilan, U.; Graber, T.E.; Alain, T.; Klokov, D. Ionizing Radiation and Translation Control: A Link to Radiation Hormesis? Int. J. Mol. Sci. 2020, 21, 6650. https://doi.org/10.3390/ijms21186650

AMA Style

Kabilan U, Graber TE, Alain T, Klokov D. Ionizing Radiation and Translation Control: A Link to Radiation Hormesis? International Journal of Molecular Sciences. 2020; 21(18):6650. https://doi.org/10.3390/ijms21186650

Chicago/Turabian Style

Kabilan, Usha; Graber, Tyson E.; Alain, Tommy; Klokov, Dmitry. 2020. "Ionizing Radiation and Translation Control: A Link to Radiation Hormesis?" Int. J. Mol. Sci. 21, no. 18: 6650. https://doi.org/10.3390/ijms21186650

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop