Potential Application of Vitamin E Superfamily for Prevention and Treatment of Human Diseases

Dear Colleagues,

After decades of research on Vitamin E, eight family members have been identified: The saturated isomers a- b- g- d-tocopherols and the unsaturated isomers a- b- g- d-tocotrienols. All members of the tocotrienol family are extensively known for their health benefits. Tocopherols have been largely reported to be found in vegetable oils, such as canola, wheat germ, sunflower oil, whereas tocotrienolss are abundant in rice bran oil, palm oil and annatto seeds. Tocotrienols and tocopherols have diverse biological activities, such as anti-oxidant, anti-inflammatory, anti-cancer, neuro-protective, skin-protection, radio-protection, improve cognition and longevity, and reduce cholesterol levels. Several important cellular functions, such as suppression of pro-inflammatory transcription factors, inhibition of HMG-CoA reductase, improving lipid profiles in non-alcoholic fatty liver disease, reducing total cholesterol, low density lipoprotein (LDL), apolipoprotein B, and triglycerides (associated with cardiovascular diseases), reducing the expression of mammalian DNA polymerases and certain protein tyrosine kinases, are all unique to the tocotrienols. This Special Issue examines in detail, and provides an update on, the molecular targets, protective effects, and modes of action of tocotrienols and tocopherols and their roles in prevention and treatment of human diseases both in preclinical animal models and clinical trials. It is probable that certain vitamin E isoform(s), such as g-tocotrienols, can be excellent protective, as well as therapeutic, agents against all human diseases that afflict mankind.

Dr. Gautam Sethi
Guest Editor

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