Dear Colleagues,

In the last decade, great improvements in the understanding of the molecular basis of both primary and metastatic brain tumors have brought critical improvement and a subsequent dramatic impact on their clinical management. Compelling evidence has demonstrated the critical role played by the molecular pattern of brain tumors on the final oncologic prognosis. With regard to intrinsic brain tumors (IBT), further developments have outlined the role of factors such as focal hypoxia, the VEGF signaling system, mitochondrial metabolism, and intracellular and transmembrane G-protein coupled receptors in the mitotic drive of neoplastic cells. Furthermore, the mechanism determining the migration along the fibers of the white matter tracts have provided in-depth explanations of the invasiveness of IBTs. With regard to brain metastases (BM), outstanding proof has shed a light over a potential role of adhesion molecules, reactive species of oxygen, and even lymphatic extracranial cells over the intracranial diffusion of the disease.

Therefore, it is our pleasure to invite investigators to contribute to this Special Issue with original research articles as well as review and meta-analysis articles aimed at promoting the diffusion of the current knowledge of the molecular basis of neuro-oncological practice. We are particularly interested in articles describing new insights into pathophysiological mechanisms, conveying potentially useful insights to achieve original diagnostic and therapeutic approaches.

Potential topics include but are not limited to the following:

• Molecular insights of glioblastoma and intrinsic brain tumor pathogenesis;
• Molecular insights concerning brain metastases pathogenesis and their diffusion inside the intracranial compartment;
• Clinical and surgical translations of the latest pathophysiological findings;
• Molecular prognostic factors in glioblastoma and intrinsic brain tumors;
• Molecular prognostic factors in brain metastases;
• Novel research approaches in primary or metastatic brain tumor investigations;
• Nutraceuticals and brain tumors;
• Autophagy related to the biology of gliomas.

Prof. Dr. Maurizio Salvati
Prof. Dr. Antonio Santoro
Dr. Alessandro Frati
Dr. Alessandro Pesce
Dr. Daniele Armocida
Dr. Placido Bruzzaniti
Guest Editors

Manuscript Submission Information

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• Glioblastoma
• Intrinsic brain tumor pathogenesis
• Low-grade gliomas
• Spinal intramedullary tumors
• Brain metastases
• Molecular pathogenesis of primary brain tumors
• Molecular pathogenesis of brain metastases