Comprehensive Research on Neuro-Oncology: From Brain Functional Anatomy to the Newest Treatments

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuro-oncology".

Deadline for manuscript submissions: closed (14 March 2025) | Viewed by 701

Special Issue Editors


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Guest Editor
Neurosurgery Division, Systems Medicine Department, University of Rome “Tor Vergata”, Rome, Italy
Interests: neuro-oncology; spine tumors; neuro-infections
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Neurosurgery Division, Systems Medicine Department, University of Rome “Tor Vergata”, Rome, Italy
Interests: neuro-oncology; spine tumors

E-Mail Website
Guest Editor
Department of Human Neurosciences, Neurosurgery Division, Università “La Sapienza” di Roma, Viale del Policlinico 155, 00161 Rome, Italy
Interests: neuro-oncology; spine tumors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, a significant number of brand-new technologies and the updated and deeper understanding of brain physiology and functional anatomy were introduced in the everyday neurosurgical practice. As a matter of fact, to date, we strongly depend on technology and advanced techniques to resect intra-axial tumors. The role of awake surgery matched with intraoperative neurophysiological monitoring and intraoperative neuropsychological testing, to intraoperatively test cognitive and motor functions in order to map their localization on the cortical surface and preserve their integrity during glioma resection, as much as the role of neuronavigation systems and neuronavigated 3D tractography to visualize the eloquent white matter tracts are some examples. 

In the present Special Issue, submissions are welcome on the role of new techniques and technologies improving the preoperative, intraoperative, and postoperative care of patients suffering from lesions involving the brain and spinal cord.

Dr. Alessandro Pesce
Prof. Dr. Maurizio Salvati
Dr. Mauro Palmieri
Guest Editors

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Keywords

  • brain
  • spine
  • tumors
  • neuro-oncology
  • technologies

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Published Papers (1 paper)

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Research

14 pages, 2327 KiB  
Article
Safety and Efficacy Evaluation of Ultrasound Aspirators in Intramedullary Spinal Cord Tumors Surgery: An Experimental Study on a Swine Model
by Mauro Palmieri, Alessandro Pesce, Mattia Capobianco, Massimo Corsini, Giorgia Iovannitti, Fulvio Aloj, Giuseppa Zancana, Vincenzo Esposito, Maurizio Salvati, Antonio Santoro, Gianpaolo Cantore and Alessandro Frati
Brain Sci. 2025, 15(7), 670; https://doi.org/10.3390/brainsci15070670 - 21 Jun 2025
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Abstract
Introduction: Intradural extramedullary and intramedullary spinal tumors are rare, complex to treat, and require advanced surgical techniques. Ultrasonic aspirators, commonly used for tumor removal, can cause sensory and motor deficits, including loss of motor evoked potentials (MEPs). This study aims to evaluate [...] Read more.
Introduction: Intradural extramedullary and intramedullary spinal tumors are rare, complex to treat, and require advanced surgical techniques. Ultrasonic aspirators, commonly used for tumor removal, can cause sensory and motor deficits, including loss of motor evoked potentials (MEPs). This study aims to evaluate the safety and efficacy of ultrasonic aspirators in intramedullary tumor surgery using a swine model, comparing different systems and techniques. Methods: Ten pigs underwent D1-D3 laminectomy and myelotomy, with adipose tissue simulating a tumor. The ultrasonic aspirators were tested under varying conditions (fragmentation power, suction, application time, and vibration mode). The primary endpoint is to evaluate the impact of the chosen variables on motor function damage. The secondary endpoints are histological evaluation of the type of damage caused by ultrasound aspirators and the effect of steroid drugs on MEPs’ impairment recovery. Results: Ultrasound aspirators can cause a significant MEP signal reduction when used in continuous mode, with fragmentation power >30 for more than 2 min (p < 0.001). Suction does not affect MEPs. When used in alternating/pulsatile mode, fragmentation power and application time do not affect MEPs. The two-way ANOVA analysis on the interaction between fragmentation power and application time in continuous mode did not demonstrate a significant interaction (p = 0.155). Time alone does not affect motor damage (p = 0.873). Betamethasone can restore MEPs’ signal after damage if administered immediately. Conclusions: Using ultrasonic aspirators in an animal model of intramedullary tumor surgery is safe. The main factor that resulted in the responsibility of motor function impairment is the fragmentation power. Full article
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