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Advanced Research on Obesity and Cancer

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (20 February 2025) | Viewed by 818

Special Issue Editor

Special Issue Information

Dear Colleagues,

Obesity is clearly related to many types of cancer, but the precise molecular mechanisms remain largely unknown. Does excess body fat/energy intake somehow trigger a normal cell to become malignant, or do fat-produced substances promote growth of malignant cells induced by other carcinogens? Conversely, perhaps some adipokine induces malignant change, and chronic caloric excess is a promoter? What is the exact role of the many molecular processes induced by obesity, including alterations in signaling pathways (p53, Notch, Wnt, and others)? What are the major adipokines driving cancer, and can these be altered by lifestyle chances or drugs?

This Special Issue will explore these and other questions. Appropriate topics include the role of excess calories in cancer as well as the specific activities of various adipokines in the malignant process. Novel hypotheses in these and other areas are needed and welcome. Precise information on the fat–cancer connection should stimulate important cancer prevention and treatment clinical research. When considering your submission, please keep in mind that IJMS is a journal of molecular science. Therefore, pure clinical studies will not be suitable for our journal. However, submissions of clinical studies that include biomolecular experiments or pathological research with case sample data are welcomed.

All authors are invited to send their research related to the topic of our Special issue, both original and review articles, to be assessed and included in the peer-review process of our journal.

Dr. Daniel W. Nixon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity
  • body fat
  • cancer
  • adipokines
  • leptin
  • adiponectin
  • angiogenesis
  • molecular activity
  • signaling pathways

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Published Papers (1 paper)

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Review

18 pages, 719 KB  
Review
Cancer-Associated Cachexia in the Era of Obesity
by Joyce Cristina Ferreira de Resende, Márcia Fábia Andrade, Fabiana Amaral Ferreira, José Pinhata Otoch, Lívia Clemente Motta-Teixeira and Marilia Seelaender
Int. J. Mol. Sci. 2025, 26(23), 11626; https://doi.org/10.3390/ijms262311626 - 30 Nov 2025
Viewed by 334
Abstract
Obesity and cancer cachexia represent opposite ends of the body mass index (BMI) spectrum. However, despite this apparent dichotomy, both conditions share critical metabolic alterations, primarily driven by inflammation, metabolic alterations and changes in adipose tissue biology. Obesity is characterised by chronic low-grade [...] Read more.
Obesity and cancer cachexia represent opposite ends of the body mass index (BMI) spectrum. However, despite this apparent dichotomy, both conditions share critical metabolic alterations, primarily driven by inflammation, metabolic alterations and changes in adipose tissue biology. Obesity is characterised by chronic low-grade inflammation and increased fat storage, while cancer cachexia involves severe weight loss, muscle atrophy, and lipolysis, with inflammation playing a central role in both conditions. Inflammatory cytokines such as TNF-α and IL-6 are increased in both scenarios, contributing to metabolic dysregulation and systemic energy imbalance. This review explores the shared inflammatory and metabolic pathways underlying obesity and cancer cachexia, with particular regard to the role of white adipose tissue (WAT). Moreover, we intend to highlight the importance of understanding the common mechanisms for the development of more effective therapeutic strategies for managing these complex metabolic disorders. Full article
(This article belongs to the Special Issue Advanced Research on Obesity and Cancer)
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