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Diagnostics
Special Issues
Dermatological Innovations: Diagnostic Advances, Therapeutic Challenges, and Laboratory Techniques
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Dermatological Innovations: Diagnostic Advances, Therapeutic Challenges, and Laboratory Techniques

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 3336

Special Issue Editor

Dr. Montserrat Fernández-Guarino

E-Mail Website
Guest Editor
Dermatology Department, Hospital Universitario Ramony Cajal, 28034 Madrid, Spain
Interests: dermatology; skin cancer; phototherapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are delighted to present our upcoming Special Editorial Issue, dedicated to "Dermatological Innovations: Diagnostic Advances, Therapeutic Challenges and Laboratory Techniques". In this edition, we aim to compile the latest innovations that are reshaping the field of dermatology, focusing on advances in molecular diagnostics and the subsequent emerging therapeutic challenges.

New molecular diagnostics in systemic inflammatory diseases such as psoriasis, neutrophilic and autoinflammatory diseases, cutaneous lymphomas, and blistering diseases have emerged, improving our knowledge and the therapeutic targeted therapies. The identification of novel molecules and future developments promise to shift the paradigm of dermatological treatment.

In this issue, these laboratory tests will be highlighted. Innovations in diagnosis are not only revolutionizing the clinical aspect of dermatology but also enabling a more precise and personalized approach through the integration of advanced laboratory tests with treatment selection. A more specific and data-driven therapeutic adjustment, derived from these advances, emerges as the key to optimizing patient care.

We invite you to participate in this fascinating Special Issue, providing a comprehensive view of the latest trends, challenges, and opportunities in the current dermatological landscape. Join us at the forefront of modern dermatology.

Dr. Montserrat Fernández-Guarino
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dermatology
  • molecular diagnostics
  • laboratory test
  • targeted therapies

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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9 pages, 397 KiB  
Article
The Skin Sebum and Moisture Levels of Children with Allergic Diseases: How Predictive Are They for House Dust Mite Allergy?
by Seda Çevik, Uğur Altaş and Mehmet Yaşar Özkars
Diagnostics 2024, 14(13), 1348; https://doi.org/10.3390/diagnostics14131348 - 25 Jun 2024
Cited by 1 | Viewed by 1488
Abstract
The aim was to evaluate the prediction of house dust mite allergy in children diagnosed with allergic disease based on their skin moisture and sebum levels. This is a case–control study including children with asthma, allergic rhinitis (AR), and atopic dermatitis (AD) and [...] Read more.
The aim was to evaluate the prediction of house dust mite allergy in children diagnosed with allergic disease based on their skin moisture and sebum levels. This is a case–control study including children with asthma, allergic rhinitis (AR), and atopic dermatitis (AD) and a healthy control group. The participants’ skin moisture and sebum levels were measured non-invasively using a digital device. A total of 421 patients and 143 healthy children were included. The median value of skin moisture percentage was statistically significantly lower in asthma, AR, and AD patients compared to the control group (p < 0.001 for each). The median value of skin sebum percentage was significantly lower in asthma and AD patients compared to the control group (p = 0.002 and p = 0.003, respectively). ROC analysis was performed to assess the predictive value of skin moisture percentage for house dust mite allergy in respiratory allergic diseases (asthma and AR) and AD separately. Using a cut-off point of 35.5% for skin moisture in asthma and AR patients, the sensitivity and specificity were 81.3% and 56.5%, respectively. Although the specificity is low, the high sensitivity value is promising. The non-invasive measurement of skin sebum and moisture could provide convenience to clinicians in the diagnosis and management of allergic diseases. Full article
(This article belongs to the Special Issue Dermatological Innovations: Diagnostic Advances, Therapeutic Challenges, and Laboratory Techniques)
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Review

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18 pages, 300 KiB  
Review
Molecular Biomarkers in Cutaneous Photodynamic Therapy: A Comprehensive Review
by Jorge Naharro-Rodriguez, Stefano Bacci and Montserrat Fernandez-Guarino
Diagnostics 2024, 14(23), 2724; https://doi.org/10.3390/diagnostics14232724 - 3 Dec 2024
Viewed by 1231
Abstract
Background/Objectives: Photodynamic therapy (PDT) is widely utilized in dermatology for the treatment of various skin conditions. Despite its effectiveness, the exact biomolecular changes underlying therapeutic outcomes remain only partially understood. This review, through a transversal approach, aims to provide an in-depth exploration of [...] Read more.
Background/Objectives: Photodynamic therapy (PDT) is widely utilized in dermatology for the treatment of various skin conditions. Despite its effectiveness, the exact biomolecular changes underlying therapeutic outcomes remain only partially understood. This review, through a transversal approach, aims to provide an in-depth exploration of molecular biomarkers involved in PDT, evaluate its underlying mechanisms, and examine how these insights can contribute to enhanced treatment protocols and personalized therapy approaches. Methods: A narrative review of the literature was conducted, targeting peer-reviewed articles and clinical trials that focus on PDT and its molecular biomarker effects on dermatological conditions. The databases searched included PubMed, Scopus, and Web of Science, and the inclusion criteria encompassed original research articles, systematic reviews, and meta-analyses in English. Results: PDT effectively reduces the expression of critical biomarkers such as p53, Cyclin D1, and Ki-67 in AK and other cancerous lesions, leading to reduced cell proliferation and increased apoptosis. Additionally, PDT promotes extracellular matrix remodeling and stimulates collagen production, which has a rejuvenating effect on the skin and a promising role in the treatment of chronic wounds. Conclusions: PDT represents a powerful and versatile treatment option for various dermatological conditions due to its ability to target cellular pathways involved in proliferation and apoptosis. Further research into optimizing treatment parameters and combining PDT with other targeted therapies may enhance patient outcomes, reduce resistance, and pave the way for more individualized therapeutic approaches in dermatology. Full article
(This article belongs to the Special Issue Dermatological Innovations: Diagnostic Advances, Therapeutic Challenges, and Laboratory Techniques)
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