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Review

Efficiency of All-Trans Retinoic Acid on Gastric Cancer: A Narrative Literature Review

by 1,2, 1,3, 1,2,3,† and 1,3,*,†
1
INSERM, U1053, Bordeaux Research in Translational Oncology, 33000 Bordeaux, France
2
Department of Digestive Surgery, Haut-Lévêque Hospital, 33000 Bordeaux, France
3
Department of Life and Health Sciences, University of Bordeaux, 33000 Bordeaux, France
*
Author to whom correspondence should be addressed.
Contributed equally to the work.
Int. J. Mol. Sci. 2018, 19(11), 3388; https://doi.org/10.3390/ijms19113388
Received: 1 October 2018 / Revised: 26 October 2018 / Accepted: 26 October 2018 / Published: 29 October 2018
(This article belongs to the Special Issue Gastric Cancers: Molecular Pathways and Candidate Biomarkers)
Gastric cancer (GC) is the third leading cause of cancer-related death worldwide with a five-year survival rate of around 25%, and 4% when diagnosed at a metastatic stage. Cancer stem cells (CSC) have recently been characterized as being responsible for resistance to radio/chemotherapies and metastasis formation, opening up perspectives for new targeted therapies. Those CSCs express biomarkers such as cluster of differentiation 44 (CD44) and display high aldehyde dehydrogenase activity that converts vitamin A-derived retinal into retinoic acids. All-trans retinoic acid (ATRA), which has pro-differentiating properties, has revolutionized the prognosis of acute promyelotic leukemia by increasing its remission rate from 15% to 85%. Recent studies have started to show that ATRA also has an anti-tumoral role on solid cancers such as GC. The purpose of this review is therefore to summarize the work that evaluated the effects of ATRA in GC and to evaluate whether its anti-cancerous action involves gastric CSCs targeting. It has been demonstrated that ATRA can block the cell cycle, enhance apoptosis, and decrease gastric CSCs properties in GC cell lines, tumorspheres, and patient-derived xenograft mice models. Therefore, retinoids and new synthetic retinoids seem to be a promising step forward in targeted therapy of gastric CSC in combination with existing chemotherapies. Future studies should probably focus on these points. View Full-Text
Keywords: tretinoin; retinoic acid; stomach neoplasms; cancer stem cell; CD44; retinoic acid receptor; retinoic X receptor; differentiation therapy tretinoin; retinoic acid; stomach neoplasms; cancer stem cell; CD44; retinoic acid receptor; retinoic X receptor; differentiation therapy
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MDPI and ACS Style

Bouriez, D.; Giraud, J.; Gronnier, C.; Varon, C. Efficiency of All-Trans Retinoic Acid on Gastric Cancer: A Narrative Literature Review. Int. J. Mol. Sci. 2018, 19, 3388. https://doi.org/10.3390/ijms19113388

AMA Style

Bouriez D, Giraud J, Gronnier C, Varon C. Efficiency of All-Trans Retinoic Acid on Gastric Cancer: A Narrative Literature Review. International Journal of Molecular Sciences. 2018; 19(11):3388. https://doi.org/10.3390/ijms19113388

Chicago/Turabian Style

Bouriez, Damien, Julie Giraud, Caroline Gronnier, and Christine Varon. 2018. "Efficiency of All-Trans Retinoic Acid on Gastric Cancer: A Narrative Literature Review" International Journal of Molecular Sciences 19, no. 11: 3388. https://doi.org/10.3390/ijms19113388

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