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Special Issue "Endothelial Dysfunction: Pathophysiology and Molecular Mechanisms"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 June 2019).
Interests: endothelial dysfunction; arterial stiffness; hypertension; atherosclerosis; metabolic syndrome; diabetes mellitus; cardiovascular risk; insulin resistance
Endothelial dysfunction is an early step of the atherosclerotic process. It is well established that the initiation and progression of disease, and its later activation to increase the risk of morbid events, depends on profound dynamic changes in vascular biology. The endothelium is emerged as the key regulator of vascular homeostasis, in that it has not merely a barrier function but also acts as an active signal transducer for circulating influences that modify the vessel wall phenotype. Alteration in endothelial function precedes the development of morphological atherosclerotic changes and can also contribute to lesion development and later clinical complications. Furthermore, in the last few decades, the relationship between vascular and metabolic diseases has been deeply investigated, demonstrating a close link between endothelial dysfunction and insulin resistance.
This Special Issue “Endothelial Dysfunction: Pathophysiology and Molecular Mechanisms” will cover a selection of recent research topics and current review articles in the field of endothelial activation in cardio-metabolic diseases.
Prof. Dr. Francesco Perticone
Prof. Dr. Salvatore Corrao
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- endothelial dysfunction
- nitric oxide
- arterial stiffness
- vascular aging
- cardiovascular risk
- insulin resistance