Dear Colleagues,

Cancer stem cells (CSCs) or tumour initiating cells are subpopulations of cancer cells that show similar characteristics to normal stem cells. Cancer is a heterogeneous disease that promotes cell growth, disables cell death mechanisms, and evades immune surveillance and therapy. CSCs are shown to be involved in tumour initiation, poor prognosis and metastasis as well as therapy resistance. In this Special Issue of IJMS, our objective is to explore the current state-of-art in our understanding of the mechanisms underpinning CSC biology contributing to tumour heterogeneity, cancer aetiology and treatment. Potential topics include: molecular mechanisms driving CSC plasticity; interaction with tumour microenviroment; immune evasion; viability and self-renewal; stemness related cell signalling and therapy resistance. Authors are invited and welcome to submit original research papers, reviews, and short communications.

Dr. Pinar Uysal Onganer
Guest Editor

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• cancer stem cells
• tumour initiating cells
• apoptosis
• cell signalling
• angiogenesis
• metastasis
• stemness markers
• metastasis
• therapy resistance