Hereditary Metabolic Diseases: The Biological Clock and Innovative Therapies
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Gene and Cell Therapy".
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 9944
Special Issue Editors
Interests: chronobiology; chronogenetics; metabolism; autophagy; oxidative stress; inflammation; aging
Special Issue Information
Dear Colleagues,
Hereditary metabolic diseases constitute a variety of congenital pathologies caused by genetic defects that have an impact on metabolism, especially within the cells of the liver. There are hundreds of hereditary metabolic diseases, caused by genetic defects of various kinds. These disorders often lead to the accumulation of substances that are toxic or that interfere with normal cellular/tissue function, or reduce the ability to synthesize essential compounds. These diseases can be life threatening or substantially debilitating, and although some dietary or enzyme-replacement therapies are available, many sustain severely unmet medical needs and often progress to organ failure, with a strong impact on life expectancy. The activity of the metabolic pathways shows circadian fluctuations, and they are rhythmically guided by the biological clock. New medical treatment strategies and advanced therapies represent an important and urgent need. Advanced therapies are innovative treatment tools and strategies that offer new opportunities for the treatment of inherited metabolic diseases for which conventional treatments have proved inadequate. Advanced therapies contain genetic material, stem cells, or tissue-engineered modified cells/tissues to be used to repair, regenerate, or replace human tissue. These therapies offer the possibility of personalizing the treatment and reducing the side effects.
For this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: hereditary metabolic diseases, the biological clock, innovative therapies, stem-cell therapy, regenerative medicine, and cell/tissue engineering.
We look forward to receiving your contributions.
Prof. Dr. Gianluigi Mazzoccoli
Prof. Dr. Roberto Tarquini
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- inborn errors of metabolism
- biological clock
- circadian rhythm
- innovative therapies
- regenerative medicine
- biotechnological drugs
- gene therapy
- stem cells
- cell reprogramming
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.