Emerging Trends in Immunodermatology and Autoimmune Skin Disorders

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: 25 October 2026 | Viewed by 1533

Special Issue Editors


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Guest Editor
Department of Biomedical, Surgical and Dental Sciences, Universita Degli Studi di Milano, Via C. Belgioioso, 173–IRCCS Ospedale Galeazzi–Sant’Ambriogio, Milan, Italy
Interests: cutaneous endotyping; pharmacovigilance and inflammatory dermatoses; cancerization field
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Guest Editor Assistant
Department of Dermatology, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Krakow, Poland
Interests: systemic lupus erythematosus; systemic sclerosis; Raynaud’s phenomenon
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of immunodermatology has undergone significant transformation over the past years, driven by growing insights into the immune system’s role in skin physiology and pathology. Autoimmune skin disorders are currently at the forefront of dermatological research thanks to advances in immunology, molecular biology, and bioinformatics. Conditions such as vitiligo, systemic sclerosis, dermatomyositis, lupus erythematosus, pemphigoid, and pemphigus have revealed complex immune-mediated mechanisms that challenge our understanding of skin disease and present new treatment perspectives.

Background and History
Historically, autoimmune skin diseases were approached through symptomatic management. Over the last two decades, the identification of key cytokines, T-cell subsets, autoantigens, and genetic risk factors has redefined our knowledge and led to the development of new treatment strategies. The advent of biologic therapies targeting specific immune pathways, such as TNF-α, IL-17, IL-23, and JAK/STAT signaling, has dramatically improved patient outcomes, and ongoing research continues to uncover novel immunological targets.

Aim and Scope of the Special Issue
This Special Issue aims to highlight the most recent advances and future directions in immunodermatology, with a focus on autoimmune skin disorders in order to present novel findings, discuss emerging therapeutic approaches, and explore the immunopathological mechanisms underlying these conditions. By bringing together interdisciplinary perspectives, we aim to foster innovation and crosstalk between basic research, clinical practice, and translational science.

Cutting-Edge Research Areas
We are particularly interested in manuscripts that explore the following areas:

  • The immunogenetics and molecular pathways involved in autoimmune skin diseases;
  • Novel biomarkers for early diagnosis, prognosis, and treatment response;
  • Innovations in targeted therapies and immunomodulatory approaches;
  • The role of the skin microbiome and environmental triggers in disease pathogenesis;
  • Systems biology, multi-omics, and artificial intelligence applications in immunodermatology;
  • Insights from clinical trials and real-world evidence in the management of these disorders;
  • Cutaneous autoimmune disorders and their clinical and systemic implications;
  • The application of imaging techniques in the diagnostic process of autoimmune skin disorders.

Authors are welcome to submit original articles, reports on novel treatment strategies and advances in decision-making, clinical outcome studies, comparative studies, narrative reviews, scoping reviews and systematic reviews and meta-analyses.

This Special Issue will serve as a timely compendium for academics, clinicians, and industry professionals seeking to stay abreast of the rapidly evolving landscape of autoimmune skin disorders and immunodermatology.

We look forward to your contributions and to advancing the frontiers of this dynamic and impactful field.

Dr. Giovanni Damiani
Guest Editor

Dr. Magdalena Spałkowska
Guest Editor Assistant

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Keywords

  • autoimmune skin disorders
  • cutaneous lupus erythematosus
  • systemic lupus erythematosus
  • autoantibodies
  • systemic sclerosis
  • dermatomyositis
  • vitiligo
  • pemphigus
  • pemphigoid

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Published Papers (1 paper)

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Research

16 pages, 1616 KB  
Article
Burden of Disease and Treatment Patterns in Adults with Atopic Dermatitis from the Baltic Region: Real-World Data from the ESSENTIAL AD Cross-Sectional Study
by Maigi Eisen, Brigita Gradauskiene, Jurate Grigaitiene, Ilona Hartmane, Külli Kingo, Ingmars Mikazans, Liisi Raam and Karin Toomela
Medicina 2026, 62(1), 84; https://doi.org/10.3390/medicina62010084 - 31 Dec 2025
Cited by 1 | Viewed by 862
Abstract
Background and Objectives: Nationwide registries that provide comprehensive insights into the atopic dermatitis (AD) population and management in routine practice are lacking in Baltic countries. Real-world studies to explore the clinical and economic burden of AD are highly needed. We present findings [...] Read more.
Background and Objectives: Nationwide registries that provide comprehensive insights into the atopic dermatitis (AD) population and management in routine practice are lacking in Baltic countries. Real-world studies to explore the clinical and economic burden of AD are highly needed. We present findings from the Baltic cohort of the larger observational study ESSENTIAL AD, conducted in Europe, the Middle East, and Africa. Materials and Methods: This cross-sectional, retrospective chart review study enrolled adult AD patients routinely managed with systemic and/or non-systemic therapy in Estonia, Latvia, and Lithuania. Data was collected during one office visit. AD severity was assessed using the Eczema Area and Severity Index (EASI) and SCORing Atopic Dermatitis (SCORAD) and impact on quality of life was assessed using the Dermatology Life Quality Index (DLQI) (primary endpoints). Results: Fifty patients were enrolled, with a mean (standard deviation [SD]) age of 33.6 (11.67) years, and 60% were women. Mean (SD) time since AD diagnosis was 21.8 (14.8) years. An equal proportion of patients received systemic therapy (including combination therapy) or non-systemic therapy (50% each). Mean (SD) EASI, SCORAD, and DLQI total scores were 9.8 (9.76), 38.0 (16.5), and 10.5 (7.1), respectively. No significant difference was observed between patients receiving systemic and non-systemic therapy in terms of EASI (mean [SD] 11.5 [12.2] versus 8.2 [6.3]; p = 0.7636), SCORAD (35.4 [20.8] versus 40.6 [11.5]; p = 0.2563), and DLQI (9.5 [7.6] versus 11.5 [6.5]; p = 0.1962). Hospitalization rate (95% confidence interval) was significantly higher in patients on systemic versus non-systemic therapy (0.4 [0.2–0.8] versus 0.1 [0.0–0.4]; p = 0.0424). Monthly out-of-pocket expenses (USD) were higher in Latvia (mean [SD]: 103.7 [2.64]) versus Estonia (55.6 [1.82]) and Lithuania (53.8 [1.90]). Conclusions: Adult AD patients from the Baltic region still face a considerable disease and economic burden, regardless of treatment received. Improved disease management and better access to guideline-recommended advanced systemic therapies are necessary. Full article
(This article belongs to the Special Issue Emerging Trends in Immunodermatology and Autoimmune Skin Disorders)
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