cimb-logo

Journal Browser

Journal Browser

Molecular Mechanisms and Therapeutic Advances in Hypertension Management and Vascular Health

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 406

Special Issue Editors


E-Mail Website
Guest Editor
Atherosclerosis and Metabolic Disease Study Center, University of Bologna, 40138 Bologna, Italy
Interests: cholesterol; hypertension; uric acid; cardiovascular risk factors; cardiovascular prevention
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, titled "Molecular Mechanisms and Therapeutic Advances in Hypertension Management and Vascular Health", will offer an in-depth exploration into the molecular mechanisms that underpin hypertension and its significant impact in cardiovascular diseases. It will focus on key areas such as endothelial function, lipid metabolism, and vascular biology, providing a comprehensive overview of the processes that contribute to the development and progression of hypertension. This Special Issue will cover a range of topics, including the pathophysiology of hypertension, gestational hypertension, and related metabolic disorders, with a particular emphasis on gene expression regulation, cholesterol metabolism, and the development of atherosclerosis.

We invite original research articles, reviews, and perspectives that investigate the latest findings in these areas, as well as exploring innovative therapeutic strategies for managing hypertension and improving vascular health. These include drug treatments for cardiovascular diseases, the mechanisms behind drug resistance, and the potential role of bioactive compounds and functional foods in the prevention and management of hypertension. Additionally, this Special Issue will explore the growing field of personalized medicine, focusing on how tailored pharmacological interventions and non-pharmacological approaches, such as lifestyle modifications and dietary strategies, can offer more effective treatment options.

By showcasing cutting-edge research from a variety of disciplines, this Special Issue will enhance our scientific understanding of cardiovascular health and hypertension. Ultimately, it will provide new insights and therapeutic avenues to improve patient outcomes, promote vascular health, and advance the treatment of cardiovascular diseases through molecular-level interventions.

Dr. Federica Fogacci
Dr. Arrigo Francesco Giuseppe Cicero
Prof. Dr. Claudio Borghi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hypertension
  • vascular aging
  • endothelial dysfunction
  • gestational hypertension
  • metabolic disorders
  • therapeutic strategies in hypertension management

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

12 pages, 629 KB  
Review
Significant Association Between Glucokinase Regulatory Protein Variants and Genetic and Metabolic Diseases
by Ke Xu, Peng Chen, Yujing Su, Yanghui Chen, Xiuli Song, Bo Yu and Hong Wang
Curr. Issues Mol. Biol. 2025, 47(10), 850; https://doi.org/10.3390/cimb47100850 - 15 Oct 2025
Viewed by 156
Abstract
As next-generation sequencing develops, there are significant associations between glucokinase regulatory protein (GCKR) variants and many diseases, especially metabolic diseases. However, there is a lack of solid descriptions and summaries of how GCKR variants lead to diseases and a lack of successful translations [...] Read more.
As next-generation sequencing develops, there are significant associations between glucokinase regulatory protein (GCKR) variants and many diseases, especially metabolic diseases. However, there is a lack of solid descriptions and summaries of how GCKR variants lead to diseases and a lack of successful translations of drugs targeting this molecular variant. We searched literature datasets, mainly including PubMed and Web of Science, with “GCKR” or “GKRP”, “Variants”, “Hypertriglyceridemia”, “NAFLD”, and “Metabolic diseases” as the search terms. Our review firstly introduces the biological function of the GCKR gene and its encoding protein GKRP and then describes the GCKR variants in different diseases, such as hypertriglyceridemia and NAFLD, revealing that GCKR/GKPR is strongly associated with metabolic diseases. GKPR might be a potential target for T2D and other metabolic diseases. One drug for interfering with the GCK-GKRP complex has been developed and has shown its effectiveness in preclinical studies, with some possible side effects. More and more different-structured drugs should be developed to improve side effects, and more clinical trials should be carried out to determine the best intervention window and timing points to improve prognosis. Taken together, these insights show that GCKR/GKRP is significantly associated with many metabolic diseases via its complex metabolism system and is a potential target in many metabolic diseases. Full article
Show Figures

Figure 1

Back to TopTop