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Unveiling Chronic Pain: Understanding Prevalence, Management, Psychiatric Comorbidity, and Inflammatory Mechanisms

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Infectious Diseases, Chronic Diseases, and Disease Prevention".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 147

Special Issue Editors

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Guest Editor
Department of Health Sciences, University West, 46186 Trollhättan, Sweden
Interests: ADHD; culture; holistic psychiatry; integrated care; neurobiology; pain; personality; substance use; trauma; yoga
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Institute for Neurodegenerative Diseases, University of Bordeaux, CNRS, UMR 5293, F-33000 Bordeaux, France
Interests: chronic pain; emotional/cognitive comorbidity; anxiety/depression; attention; ADHD; neuroinflammation; neuropeptides; cingulate cortex; spinal cord

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Guest Editor
Faculty of Health Science and Institute of Advanced Materials (INAM), University Jaume I, 12071 Castellon, Spain
Interests: neuroinflammation; psychiatric disorders; insulin resistance; chitosan nanoparticles; AAV particles; non-coding RNA; animal models; cell culture
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chronic pain affects approximately 20% of the world's population, thus posing both a prevalent and a daunting healthcare challenge. This Special Issue critically synthesizes the current knowledge on the global burden of chronic pain, elucidating its intricate association with psychiatric disorders and the emergent insights into the role of inflammation, as well as investigating how biological, behavioral, psychosocial, and environmental factors profoundly affect individuals suffering from chronic pain, ultimately impacting their quality of life.

This Special Issue is dedicated to comprehensively exploring the prevalence of chronic pain and its intricate links to psychiatric disorders, with a special emphasis on the pivotal role of inflammation. Moreover, it aims to offer fresh perspectives on effective pain management. This compilation ranges from foundational biological insights to behavioral studies that shed light on psychosocial aspects of chronic pain to an investigation of its contributing environmental factors. Leveraging rigorous study designs, solid theoretical frameworks, and methodological precision, we hope the contributions within this Special Issue could unravel the intricate relationship between chronic pain and psychiatric disorders, offering an exhaustive, evidence-based exploration of these interconnected phenomena while also illuminating the pervasive role of inflammation and proposing strategies to enhance the quality of life of those affected. We underscore the effectiveness of multidisciplinary research, leading clinicians and researchers toward a more profound understanding of chronic pain, as well as endeavor to bridge the gap between scientific discovery and clinical practice, emphasizing innovative approaches to management and care.

By encapsulating diverse perspectives and fostering cross-disciplinary dialogue, this Special Issue is devoted to addressing the multifaceted challenges posed by chronic pain. It seeks to advance the healthcare field by integrating various research strands into a coherent framework that enriches our comprehension of this complex condition.

In conclusion, this Special Issue is intended to stand as a compendium of cutting-edge interdisciplinary works, at the crossroads of scientific progress and advances in medical practice , with the aim of improving patient outcomes through a synergistic exploration of the biological, psychosocial, and environmental dimensions of chronic pain. It underscores the necessity for high-quality research that is not only methodologically rigorous but also innovative and aligned with the practical imperatives of improving the quality of life for millions of affected patients.

Prof. Dr. Nóra Kerekes
Prof. Dr. Marc Landry
Prof. Dr. Ana María Sánchez-Pérez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • chronic pain
  • psychiatric disorders
  • inflammation
  • quality of life
  • evidence-based investigations
  • innovative pain management
  • interdisciplinary evidence
  • healthcare challenges

Published Papers

This special issue is now open for submission.
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