International Journal of Environmental Research and Public Health

Journal Browser

► Journal Browser

Special Issue Editor

Dr. Salma I. Patel

E-Mail Website
Guest Editor

UAHS Center for Sleep and Circadian Sciences and Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona, Tucson, AZ 85724, USA
Interests: sleep medicine; sleep apnea; cardiovascular outcomes

Special Issue Information

Dear Colleagues,

Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder and is characterized by recurrent episodes of a complete or partial obstruction of the upper airway, leading to reduced or absent breathing during sleep. In recent decades, the prevalence of OSA has greatly increased, making it one of the most commonly diagnosed sleep disorders, thus affecting the quality of life of a vast number of individuals. If left untreated, OSA is associated with adverse cardiovascular outcomes such as myocardial infraction, heart failure, pulmonary hypertension, systemic hypertension, arrhythmias, sudden death and general mortality. There are many standard treatments for obstructive sleep apnea and some upcoming treatments. This issue will provide an update of the existing and upcoming treatments. We invite you to contribute to this Special Issue with high-quality and original studies, review papers, and meta-analysis.

Dr. Salma I. Patel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

obstructive sleep apnea
sleep disordered breathing
sleep apnea
outcomes
mortality

Published Papers (1 paper)

Research

9 pages, 1320 KiB

Open AccessArticle

Short-Term Outcome of Unilateral Inspiration-Coupled Hypoglossal Nerve Stimulation in Patients with Obstructive Sleep Apnea

by Johannes Pordzik, Christopher Seifen, Katharina Ludwig, Tilman Huppertz, Katharina Bahr, Christoph Matthias and Haralampos Gouveris

Int. J. Environ. Res. Public Health 2022, 19(24), 16443; https://doi.org/10.3390/ijerph192416443 - 8 Dec 2022

Cited by 2 | Viewed by 2147

Abstract

Hypoglossal nerve stimulation (HGNS) is a therapeutic option for patients with obstructive sleep apnea (OSA) and intolerance of positive airway pressure (PAP) therapy. Most reported data are based on multicentre pivotal trials with selected baseline core clinical features. Our aim was to investigate polysomnography (PSG)-based outcomes of HGNS-therapy in a patient cohort with higher average AHI and BMI than previously reported. Data of 29 consecutive patients (nine female; mean age: 55.52 ± 8.6 years, mean BMI 30.13 ± 3.93 kg/m²) were retrospectively evaluated. Numerical values of PSG- based metrics were compared before and after intervention using Wilcoxon’s rank-sum test. AHI (38.57/h ± 12.71, 24.43/h ± 13.3, p < 0.001), hypopnea index (24.05/h ± 9.4, 15.27/h ± 8.23, p < 0.001), apnea index (14.5/h ± 12.05, 9.17/h ± 10.86, p < 0.01), snoring index (262.68/h ± 170.35, 143.48/h ± 162.79, p < 0.001), cortical arousal index (20.8/h ± 10.34 vs. 14.9/h ± 8.36, p < 0.01) and cumulative duration of apnea and hypopnea during sleep (79.79 min ± 40.32 vs. 48.62 min ± 30.56, p < 0.001) were significantly lower after HGNS. HGNS provides an effective therapy option for selected patients not tolerating PAP-therapy with higher average AHI and BMI than usually reported. HGNS-therapy appears to suppress central nervous system arousal circuits while not eliciting peripheral autonomous sympathetic activation. Such metrics as the snoring index and the cumulative duration of respiratory events during sleep may be considered in future HGNS studies. Full article

(This article belongs to the Special Issue Advance in Obstructive Sleep Apnoea Treatment)

► Show Figures

Figure 1

Journal Menu

Journal Browser

Advance in Obstructive Sleep Apnoea Treatment

Share This Special Issue

Special Issue Editor

Special Issue Information

Keywords

Published Papers (1 paper)

Research

Further Information

Guidelines

MDPI Initiatives

Follow MDPI