Periodontal Disease: Current Non-Surgical Strategies and Surgical Treatments

A special issue of Healthcare (ISSN 2227-9032).

Deadline for manuscript submissions: 15 February 2026 | Viewed by 367

Special Issue Editors


E-Mail Website
Guest Editor
Dentistry and Maxillo-Facial Surgery Unit, Department of Surgery, Dentistry, Paediatrics and Gynaecology (DIPSCOMI), University of Verona, Piazzale L.A. Scuro 10, 37134 Verona, Italy
Interests: periodontology; peri-implantology; prevention; regenerative therapies and biomaterials; oral surgery
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
School of Dentistry, Department of Surgery, Dentistry, Paediatrics and Gynaecology (DIPSCOMI), University of Verona, Piazzale L.A. Scuro 10, 37134 Verona, Italy
Interests: periodontology; dental implantology; oral implantology; dentistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is well known that the bacterial aetiology and inflammatory pathogenesis of periodontitis lead to the progressive destruction of soft and hard tissues that are essential in ensuring support and tooth stability. Moreover, the dysbiosis of the commensal oral microbiota (dental plaque), interacting with host immune defences, leads to a widespread chronic biological response, with clinical phases of activity and quiescence.

In the light of these considerations, the precise and correct assessment of periodontal defects constitutes a fundamental aspect of therapeutic planning, both in non-surgical and surgical approaches.

In recent decades, non-surgical strategies have mainly focused on the employment of techniques (e.g., ozone, laser, hyperbaric oxygen therapy, hyaluronic acid, and topical agents) that can disaggregate the biofilm and reduce signs of inflammation, with eventual implications for bone gain.

On the other hand, the risk of disease progression, in terms of residual periodontal pockets during supportive periodontal treatment following cause-related therapy, usually requires further surgical treatment, which is currently performed with optimal regenerative biomaterials (homologous/xenologous bone or resorbable synthetic materials, in association with, or unrelated to, collagen membranes).

We are pleased to invite you to submit manuscripts highlighting updated indications, features, and applications of novel approaches or giving an overview of current non-surgical strategies and surgical treatments for periodontitis.

This Special Issue will present clinical and scientific contributions (research articles, systematic reviews, and case reports) and future directions for specific non-surgical and surgical care in periodontal disease.

For this Special Issue, original research articles and reviews are welcome. Research may include (but is not limited to) periodontology and related fields of research.

We look forward to receiving your contributions.

Dr. Alessia Pardo
Dr. Giorgio Lombardo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Healthcare is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • periodontal care
  • prevention
  • oral microbiota
  • inflammatory response
  • immunological response
  • systemic diseases
  • minimally invasive instrumentation
  • non-surgical therapy
  • surgical therapy
  • topical agents
  • laser
  • ozone
  • hyaluronic acid
  • regenerative biomaterials
  • bone regeneration
  • osteoconductive

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Other

25 pages, 2239 KiB  
Systematic Review
The Adjunctive Role of Antimicrobial Photodynamic Therapy to Non-Surgical Treatment in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
by Alessia Pardo, Annarita Signoriello, Elena Messina, Elia Stilo, Rachele De’ Manzoni Casarola, Elisabetta Ferrara, Giorgio Lombardo and Massimo Albanese
Healthcare 2025, 13(14), 1703; https://doi.org/10.3390/healthcare13141703 - 15 Jul 2025
Viewed by 251
Abstract
Background: This systematic review aimed to assess the outcomes related to the use of antimicrobial photodynamic therapy (aPDT) as an adjunct to non-surgical periodontal treatment (NSPT) of patients affected by periodontitis and with type 2 diabetes mellitus (T2DM). Methods: PubMed, Cochrane Library, Scopus, [...] Read more.
Background: This systematic review aimed to assess the outcomes related to the use of antimicrobial photodynamic therapy (aPDT) as an adjunct to non-surgical periodontal treatment (NSPT) of patients affected by periodontitis and with type 2 diabetes mellitus (T2DM). Methods: PubMed, Cochrane Library, Scopus, and Web of Science (core collection) were queried up to January 2025. The PICO question investigated the comparison between T2DM patients undergoing NSPT with or without aPDT, in terms of improvement of clinical parameters. Two independent operators performed the study selection, data extraction, and risk of bias assessment (RoB-2 tool). The meta-analysis examined the reduction in bleeding on probing (BoP) and probing pocket depth (PPD) in sites > 4 mm, reporting mean difference (MD) and 95% confidence intervals (CIs). Results: Among 502 studies retrieved, 15 were finally included in the systematic review and meta-analysis. In T2DM individuals, the adjunct of aPDT to NSPT demonstrated a substantial reduction in BoP and PPD after 3 and 6 months compared to the use of NSPT alone. Conclusions: The outcomes of this systematic review suggest that adjunctive aPDT may provide additional benefit to NSPT in reducing inflammation in T2DM patients with periodontitis, indicating that this combined therapy could represent a potentially useful approach for individuals with T2DM. Review registration: registration in PROSPERO (International prospective register of systematic reviews) with ID CRD42024506295 on 6 February 2024. Full article
Show Figures

Figure 1

Back to TopTop