Parkinson’s Disease: Diagnosis, Treatment and Care

A special issue of Healthcare (ISSN 2227-9032). This special issue belongs to the section "Chronic Care".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 796

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Guest Editor
Department of Medicine, Surgery and Dentistry, Neuroscience Section, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Baronissi, 84131 Salerno, Italy
Interests: apathy; cognitive impairment; progressive supranuclear palsy; multiple system atrophy; Parkinson; neurodegenerative disorders; functional neurological disorders
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Special Issue Information

Dear Colleagues,

Parkinson's Disease (PD) is the second most common neurodegenerative disease.

The diagnosis of PD is predominantly clinical. The sign needed to diagnose PD is the presence of akinesia associated with one of the other signs, such as muscle rigidity, resting tremor or postural instability. But PD is characterized by the association of motor, sensory, autonomic, cognitive and psychiatric symptoms.

Direct evidence shows the possible presence in the prodromal phase of olfactory disorders, REM sleep behavioral disorders, constipation, visual alterations, other autonomic symptoms, cognitive deficits and depression. However, the specificity and predictive value of these markers are still considered insufficient and cannot yet be used alone. For this reason, it appears increasingly necessary to better characterize the prodromal phases, which allow the diagnosis to be anticipated.

Many drugs are used for PD symptoms and others are being tested, but given the multi-component nature of the disease, physiotherapy, cognitive rehabilitation and psychological support for the patients and caregivers are also receiving attention.

Given that the number of Parkinson's cases is expected to double in the coming years, future studies must be oriented towards finding motor and non-motor markers that can facilitate early diagnosis. Furthermore, it is also important to identify other systematic pharmacological and non-pharmacological treatments.

Therefore, we will accept original research articles, critical and systematic reviews, meta-analyses and short communications leading to a greater understanding of the diagnosis, treatment and care of Parkinson's Disease.

Dr. Sofia Cuoco
Guest Editor

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Keywords

  • cognitive symptoms
  • care
  • diagnosis
  • motor symptoms
  • neuropsychiatric symptoms
  • non-pharmacological treatments
  • Parkinson's disease
  • pharmacological treatments
  • prodromal phase

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Published Papers (1 paper)

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Research

14 pages, 390 KiB  
Article
Parkinson’s Disease Caregiving, Level of Care Burden, Caregiving-Related Strain, and Caregiver Health
by Julie S. Olson, Reema Persad-Clem, George C. Kueppers, Fawn A. Cothran and Margaret L. Longacre
Healthcare 2025, 13(13), 1520; https://doi.org/10.3390/healthcare13131520 - 26 Jun 2025
Viewed by 232
Abstract
Background: Caregiving can be a challenging experience, particularly for caregivers of people with Parkinson’s disease, given the array of motor and neuropsychiatric symptoms. Elevated care tasks and demands related to these symptoms may result in greater care burden, heightened caregiving-related strain, and, in [...] Read more.
Background: Caregiving can be a challenging experience, particularly for caregivers of people with Parkinson’s disease, given the array of motor and neuropsychiatric symptoms. Elevated care tasks and demands related to these symptoms may result in greater care burden, heightened caregiving-related strain, and, in turn, poorer health for Parkinson’s disease (PD) caregivers compared to non-PD caregivers. Guided by the Stress Process Model, the purpose of this study was to explore the pathways connecting PD caregiving and caregiver health, with attention to the role of care burden and caregiving-related strain. Methods: We applied path analysis in a structural equation modeling framework to data from 3116 PD and non-PD caregivers participating in the National Alliance for Caregiving and AARP’s Caregiving in the U.S. 2015 and 2020 surveys. We estimated pathways between PD caregiving, care burden, caregiving-related strain (i.e., emotional, physical, and financial), and caregiver self-reported health simultaneously, then decomposed these pathways into total, indirect, and direct effects. Results: Findings show PD caregiving is indirectly linked to poorer health among caregivers through increased care burden and heightened caregiving-related strain, with additional path analysis models pointing to physical strain as an important component of caregiving-related strain in mediating the associations between PD caregiving and overall health. Conclusions: Our findings suggest a need to be especially attentive to the accumulation of care burden and caregiving-related strain—particularly physical strain—among PD caregivers, given the potential consequences for caregiver health. Solutions are needed, such as caregiver screening and caregiver-specific care plans, to better support reductions in burden and strain among PD caregivers, thereby promoting their overall health. Full article
(This article belongs to the Special Issue Parkinson’s Disease: Diagnosis, Treatment and Care)
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