Physical Activity and Chronic Pain Management

A special issue of Healthcare (ISSN 2227-9032).

Deadline for manuscript submissions: closed (31 March 2026) | Viewed by 1062

Editor


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Guest Editor
Department of Physical Therapy, Faculty of Medicine, University of Chile, Santiago 8240000, Chile
Interests: chronic musculoskeletal pain; physical activity; exercise; rehabilitation; pain education

Special Issue Information

Dear Colleagues,

Chronic musculoskeletal pain is a major public health problem worldwide and a leading cause of disability. Physical activity and exercise programs are widely recognized as effective non-pharmacological strategies for pain relief, functional improvement and improved quality of life. However, participation in physical activity remains suboptimal among people living with chronic pain due to a complex interplay of biological, psychological, and social factors.

We are pleased to invite you to contribute to this Special Issue of Healthcare, which aims to explore the role of physical activity in the management of chronic musculoskeletal pain. We seek to highlight recent advances in exercise-based interventions, identify barriers and facilitators to physical activity participation, and discuss strategies for tailoring and optimizing physical activity programs in this population.

Original research articles and reviews are welcome in this Special Issue. Areas of research may include (but are not limited to) the following:

  • Benefits of physical activity in individuals with chronic musculoskeletal pain.
  • Social and environmental barriers to physical activity in chronic pain
  • Person-centered approaches and adaptations in exercise therapy.
  • Pain science education and rehabilitation in chronic pain.
  • Lifestyle-based interventions for pain management.
  • Digital tools and technologies to support physical activity.

We look forward to receiving your contributions.

Dr. Rodrigo Núñez-Cortés
Guest Editor

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Keywords

  • chronic musculoskeletal pain
  • physical activity
  • exercise therapy
  • social barriers
  • lifestyle interventions
  • biopsychosocial model
  • rehabilitation
  • quality of life
  • digital health
  • telerehabilitation

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Published Papers (1 paper)

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Research

12 pages, 874 KB  
Article
Synovial Fluid Characteristics and Pain Recovery Trajectory Following Rehabilitation in Patients with Meniscal Tears: A Retrospective Cohort Study
by Murat Baloğlu
Healthcare 2026, 14(7), 962; https://doi.org/10.3390/healthcare14070962 - 6 Apr 2026
Viewed by 484
Abstract
Background: Meniscal tears are a common cause of knee pain and functional limitation, yet determinants of pain recovery following rehabilitation remain incompletely understood. Structural imaging findings often show limited correlation with clinical symptoms. This study aimed to evaluate longitudinal pain trajectories after rehabilitation [...] Read more.
Background: Meniscal tears are a common cause of knee pain and functional limitation, yet determinants of pain recovery following rehabilitation remain incompletely understood. Structural imaging findings often show limited correlation with clinical symptoms. This study aimed to evaluate longitudinal pain trajectories after rehabilitation in patients with meniscal tears and to investigate whether synovial fluid characteristics and structural joint degeneration are associated with pain improvement. Methods: This retrospective cohort study included 59 patients with meniscal tears who underwent structured rehabilitation. Structural degeneration was assessed using the Whole-Organ Magnetic Resonance Imaging Score (WORMS). Synovial fluid cytology evaluated neutrophil predominance (PNL) and erythrocyte positivity. Pain intensity was measured using the Visual Analog Scale (VAS) at 3 months, 6 months, and 1 year. Longitudinal changes were analyzed using the Friedman test, and predictors of pain improvement (ΔVAS from 3 months to 1 year) were evaluated using multivariable linear regression. Results: VAS scores decreased significantly over time (p < 0.001), indicating sustained pain reduction during follow-up. In the multivariable regression model (F(4, 54) = 2.80, p = 0.035), 17% of the variance in pain improvement was explained (R2 = 0.17). Synovial erythrocyte positivity was modestly associated with greater longitudinal pain reduction (β = 0.75, 95% CI 0.15–1.36, p = 0.016). Age was also a significant predictor (β = 0.025, p = 0.043), whereas WORMS score and PNL positivity were not significantly associated with pain improvement. Conclusions: Pain recovery following rehabilitation in patients with meniscal tears appears to be influenced more by intra-articular biological characteristics than by structural imaging severity alone. Synovial erythrocyte positivity may indicate a potentially reversible inflammatory phenotype associated with higher early pain but greater subsequent improvement. These findings support a multidimensional model of knee pain and suggest that synovial characteristics may help improve clinical risk stratification during rehabilitation planning. Full article
(This article belongs to the Special Issue Physical Activity and Chronic Pain Management)
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