Obesity Treatment, Metabolic Disorders and Diet

A special issue of Healthcare (ISSN 2227-9032). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (1 December 2023) | Viewed by 2905

Special Issue Editor


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Guest Editor
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
Interests: obesity; gut microbiota; functional foods; prebiotics; probiotics; pancreatic cancer; colorectal cancer

Special Issue Information

Dear Colleagues,

Metabolic disorders such as obesity, insulin resistance, and diabetes are the most common diseases in the present scenario, and these are associated with various cancers. Lifestyle changes, viz. Western diet intake, smoking, alcohol, and environmental factors, are key players. Further, altering the gut microflora, termed “dysbiosis”, leads to inflammation and disease progression which alters intestinal homeostasis. Gut microbiota plays a prominent role in ameliorating obesity and its associated disorders, including cancers. Therefore, treatment of metabolic syndromes via herbal supplements, diet, functional foods, milk products, and pre- and probiotics would be beneficial. Therefore, we are pleased to invite you to contribute research and review articles to this Special Issue, including but not limited to the following:

  1. Obesity management via fiber, pre-, and probiotics and functional foods;
  2. Targeting the gut microbiota in obesity-associated metabolic diseases and cancers;
  3. Current challenges associated with obesity and its associated disorders;
  4. Therapeutic approaches to target obesity-associated cancer;
  5. Gut–brain axis to modulate metabolic diseases;
  6. Animal and clinical studies.

We look forward to receiving your contributions.

Dr. Ramesh Pothuraju
Guest Editor

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Keywords

  • obesity
  • metabolic diseases
  • cancers
  • lifestyle
  • dietary factors

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Published Papers (1 paper)

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Research

12 pages, 1266 KiB  
Article
Relationship between Composite Dietary Antioxidant Index and Aging
by Haiting Wang and Yongbing Chen
Healthcare 2023, 11(20), 2722; https://doi.org/10.3390/healthcare11202722 - 12 Oct 2023
Cited by 7 | Viewed by 2528
Abstract
Background: Numerous studies have demonstrated a close relationship between antioxidant-rich diets and comorbidities as well as mortality. However, the relationship between such diets and aging remains unclear. The purpose of this study was to investigate the association between the Composite Dietary Antioxidant Index [...] Read more.
Background: Numerous studies have demonstrated a close relationship between antioxidant-rich diets and comorbidities as well as mortality. However, the relationship between such diets and aging remains unclear. The purpose of this study was to investigate the association between the Composite Dietary Antioxidant Index (CDAI) and aging. Methods: All participants were from the National Health and Nutrition Examination Survey (NHANES) 2001–2010. Phenotypic age was calculated using a formula and subtracted from the chronological age to determine the aging. When the phenotypic age exceeded the chronological age, it was considered as aging. A weighted logistic regression model was employed to explore the relationship between CDAI and aging. Restricted cubic splines (RCSs) were used to examine the potential nonlinear relationship between them. Subgroup analysis and joint analysis were conducted to explore the effect of modifiers in these relationships. Results: A total of 19,212 participants (weighted: 165,285,442 individuals) were included in this study. The weighted logistic regression model showed a significant correlation between CDAI and the risk of aging (OR = 0.90, 95% CI: 0.84–0.96). RCS analysis revealed an L-shaped dose–response relationship between CDAI and the risk of aging. Subgroup analysis indicated that the association between CDAI and aging was more pronounced in middle-aged individuals and non-smokers. The joint analysis demonstrated that although smoking accelerated aging among participants, a high CDAI diet could still offset these damages. Conclusions: The association between high CDAI and reduced risk of aging is particularly significant in young and middle-aged individuals and non-smokers. Consuming foods rich in CDAI components may potentially lower the risk of aging. Full article
(This article belongs to the Special Issue Obesity Treatment, Metabolic Disorders and Diet)
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