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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Differentially Expressed Genes (DEGs) and Regulatory Network in Response to Various Abiotic Stresses in Plants

edited by Xuke Lu

submission deadline 30 Oct 2025 | 1 articles | Viewed by 551 | Submission Open

Keywords: plants; abiotic stresses; molecular mechanism; differentially expressed genes (DEGs); regulatory network

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetics and Epigenetics in Susceptibility to Multifactorial Diseases

edited by

Cinzia Ciccacci

and Andrea Latini

submission deadline 30 Oct 2025 | Viewed by 154 | Submission Open

Keywords: multifactorial disorders; genetic factors; epigenetic factors; polymorphisms; gene– gene interactions; gene– miRNA interactions; miRNA; methylation state; genetic susceptibility

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Progress and Applications of Sequencing Technologies

edited by

Domenico Giosa

and Maria Papale

submission deadline 30 Oct 2025 | Viewed by 119 | Submission Open

Keywords: genomics; transcriptomics; epigenomics; metagenomics; bioinformatics; data analysis

(This special issue belongs to the Section Technologies and Resources for Genetics)

Advances in Prenatal and Postnatal Genetic Testing: Precision Diagnosis for Genetic Disorders

edited by

Spiros Vittas

and Eirini Louizou

submission deadline 30 Oct 2025 | Viewed by 117 | Submission Open

Keywords: genetic testing; prenatal diagnosis; postnatal diagnosis; precision medicine

(This special issue belongs to the Section Genetic Diagnosis)

Epigenetic Dynamics in Cancer and Aging

edited by

Hayan Lee

submission deadline 30 Oct 2025 | Viewed by 103 | Submission Open

Keywords: DNA methylation; histone modification; chromatin 3D modeling; non-coding RNA; long-read sequencing technology; single-cell epigenetics; cancer initiation and development; epigenetic alterations in the aging process; aging-specific epigenetic alterations; cancer-specific epigenetic alterations

(This special issue belongs to the Section Epigenomics)

Genetic Breeding and Genomics of Vegetables

edited by

Hanqiang Liu

, Kailiang Bo and Biao Jiang

submission deadline 30 Oct 2025 | Viewed by 47 | Submission Open

Keywords: vegetable breeding; germplasm innovation; functional genomics; molecular breeding; genome editing; genetic mapping; stress resistance; transcriptomics; bioinformatics

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Status and Perspectives of Fisheries Resources

edited by Wei Wang

submission deadline 31 Oct 2025 | Viewed by 109 | Submission Open

Keywords: population genetics; aquaculture breeding and biotechnology; fisheries resource conservation and sustainable utilization; fisheries resource management; genetic technology and methods; climate change and genetic responses

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetics and Genomics of Endocrine Diseases in Children and Adolescents

edited by

Malgorzata Wasniewska

submission deadline 31 Oct 2025 | Viewed by 70 | Submission Open

Keywords: endocrine disease; endocrine gland; genetic syndrome; genetic polymorphism; genetic pathomechanism

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Reproduction in Pigs

edited by Rui Cai

submission deadline 31 Oct 2025 | Viewed by 50 | Submission Open

Keywords: pig; spermatogenesis; semen preservation; reproductive technology; genomic selection

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic, Epigenetic and Environmental Factors in Dental Development and Pathologies: Genes, Interactions and Dental Development

edited by

Alan H. Brook

submission deadline 5 Nov 2025 | 14 articles | Viewed by 36259 | Submission Open

Keywords: dental development; genetics; epigenetics; complex adaptive systems; interactive networks

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics in Motor Neuron Diseases

edited by

Christopher Grunseich

submission deadline 5 Nov 2025 | Viewed by 278 | Submission Open

Keywords: motor neuron disease; familial amyotrophic lateral sclerosis (fALS); gene therapy; antisense oligonucleotides (ASOs); precision medicine; novel therapeutic approaches

(This special issue belongs to the Section Neurogenomics)

Advances in Pharmacogenomics of Human Diseases

edited by

Maria Papasavva

and Alexander Haliassos

submission deadline 10 Nov 2025 | Viewed by 403 | Submission Open

Keywords: pharmacogenomics; precision medicine; genetic variants; disease susceptibility; clinical genetics; individualized treatment; biomarkers

(This special issue belongs to the Section Pharmacogenetics)

Genetics and Genomics of Lung Cancer

edited by Elisa Frullanti

submission deadline 10 Nov 2025 | Viewed by 351 | Submission Open

Keywords: lung cancer; genetic variants; genomics; biomarkers; pharmacogenomics; targeted therapy

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Gene Therapy

edited by Ryan Butler

submission deadline 10 Nov 2025 | Viewed by 259 | Submission Open

Keywords: gene therapy; rare diseases; viral vectors; RNA silencing; gene editing; methylation editing

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Pharmacogenomics and Personalized Treatment

edited by

Livija Šimičević

and Lana Ganoci

submission deadline 10 Nov 2025 | Viewed by 62 | Submission Open

Keywords: pharmacogenomics; personalized treatment; genetic biomarkers; drug metabolism; gene– drug interactions; genetic variation; clinical pharmacogenomics

(This special issue belongs to the Section Pharmacogenetics)

Advances in Genomics and Epigenetics of Hearing Loss

edited by Alessandro Castiglione

submission deadline 15 Nov 2025 | Viewed by 94 | Submission Open

Keywords: genetics; hearing loss; inner ear; epigenetics; auditory system

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Genomics of Autism Spectrum Disorders

edited by

Roberto Canitano

and

Marco Carotenuto

submission deadline 15 Nov 2025 | Viewed by 68 | Submission Open

Keywords: autism spectrum disorders; genetics; new techniques for diagnosis

(This special issue belongs to the Section Neurogenomics)

Next-Generation Sequencing in Rare Genetic Diseases

edited by

Edoardo Errichiello

and

Paola Dimartino

submission deadline 15 Nov 2025 | Viewed by 63 | Submission Open

Keywords: rare genetic diseases; next-generation sequencing; bioinformatics; multiomics data; artificial intelligence; gene discovery; single nucleotide variants; structural variants

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Immunogenetics and Functional Genomics of Insects

edited by

Zhizhi Wang

and Fei Wang

submission deadline 15 Nov 2025 | Viewed by 40 | Submission Open

Keywords: host– microbe interaction; microbial infection; insect immunity; immune gene evolution; innmue response; crosstalk

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetics of Cancer Immunology

edited by

Jing Yang

submission deadline 20 Nov 2025 | 1 articles | Viewed by 981 | Submission Open

Keywords: tumor– immune interaction; immunotherapy; immune regulation; immune evasion

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Analysis of Hepatitis Virus Infection

edited by

Dan Florin Mihǎilescu

and

Maria Alexandra Mernea

submission deadline 20 Nov 2025 | Viewed by 114 | Submission Open

Keywords: hepatitis virus; viral genomics; host genetics; immune response; biomarkers; pathogenesis; next-generation sequencing; personalized medicine; gene– environment interactions; antiviral therapy

(This special issue belongs to the Section Viral Genomics)

HTAAD: Unraveling the Molecular and Clinical Complexity of Heritable Thoracic Aortic Disease

edited by

Guglielmina Pepe

, Rossella Fattori,

Stefano Nistri

and Yskert von Kodolitsch

submission deadline 20 Nov 2025 | Viewed by 57 | Submission Open

Keywords: syndromic and non-syndromic HTAAD; Loeys– Dietz syndrome; Marfan syndrome; vascular Ehlers– Danlos syndrome; bicuspid aortic valve; genotype– phenotype correlation; next-generation sequencing (NGS) and omics technologies; extracellular matrix; TGF-β signaling pathway and smooth muscle cell contraction genes; iconodiagnostic

(This special issue belongs to the Section Genetic Diagnosis)

Application of Sequencing Technologies in Cancers

edited by Limin Chen

submission deadline 20 Nov 2025 | Viewed by 49 | Submission Open

Keywords: sequencing technologies; single-cell; spatial transcriptomics; cancer

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Breeding Improvements in Sheep and Goat

edited by Kaiping Deng

submission deadline 20 Nov 2025 | Viewed by 45 | Submission Open

Keywords: genetics; breeding improvement; genomic selection; molecular markers

(This special issue belongs to the Section Animal Genetics and Genomics)

Molecular Adaptation and Evolutionary Genetics in Plants

edited by Wei Zhang

submission deadline 24 Nov 2025 | 3 articles | Viewed by 2187 | Submission Open

Keywords: molecular evolution; plastid genome; mitochondrial genome; nuclear genome; gene family

(This special issue belongs to the Section Plant Genetics and Genomics)

Molecular Genetics and Pathogenesis of Motor Neuron Disease

edited by Tadashi Nakagawa

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1362 | Submission Open

Keywords: motor neuron disease; molecular genetics; molecular and cellular analyses; phenotypic characterization; therapeutic development; clinical applications; omic technologies

(This special issue belongs to the Section Neurogenomics)

AI and Machine Learning in Cancer Genomics

edited by

S M Ashiqul Islam

submission deadline 25 Nov 2025 | Viewed by 134 | Submission Open

Keywords: genomics; cancer; AI; ML; tools; signatures; biomarkers; oncology

(This special issue belongs to the Section Bioinformatics)

Genetic and Genomic Innovations for Developing Resilient Crops

edited by

Huajin Sheng

and

Sheng Wang

submission deadline 25 Nov 2025 | Viewed by 130 | Submission Open

Keywords: crop improvement; abiotic stress; gene function; transcriptomics; gene editing; molecular breeding

(This special issue belongs to the Section Plant Genetics and Genomics)

New Developments in Pediatric Clinical Genetics and Metabolic Diseases

edited by Laura L. Konczal and Chen-Han Wilfred Wu

submission deadline 25 Nov 2025 | Viewed by 109 | Submission Open

Keywords: inherited metabolic disease; gene therapy; CRISPR; mRNA; pediatric genetics; rare inherited disease; whole genome sequencing; diagnosis of rare disorders; treatment of rare disorders; newborn screening

(This special issue belongs to the Section Genetic Diagnosis)

Genetics in Thyroid Cancer

edited by

Tatjana Bogovic Crncic

and Tomislav Jukić

submission deadline 25 Nov 2025 | Viewed by 86 | Submission Open

Keywords: genetic mutations; thyroid cancer; molecular diagnostics; risk stratification; novel therapies; MAPK/PI3K-AKT signalling; radioiodine-refractory; redifferentiation therapeutic strategies; tumour genomic profiling; targeted therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

15th Anniversary of Genes: Feature Papers in “Neurogenetics and Neurogenomics”

edited by

Claudia Ricci

and Micheal Palladino

submission deadline 25 Nov 2025 | Viewed by 65 | Submission Open

Keywords: genomics; neurological diseases; multi-omics studies; brain development and function; precision medicine; pathogenic mechanisms

(This special issue belongs to the Section Neurogenomics)

Genetics of Neurodevelopmental Disorders, Pathogenesis, and Precision Therapies

edited by Andrea L. Gropman

submission deadline 25 Nov 2025 | Viewed by 49 | Submission Open

Keywords: biochemical genetics; brain imaging; fNIRs; metabolism; child neurology; developmental disorders

(This special issue belongs to the Section Neurogenomics)

Diagnosis and Treatment of Inherited Breast Cancer

edited by Maja Prutki and

Ivo Dumić-Čule

submission deadline 25 Nov 2025 | Viewed by 47 | Submission Open

Keywords: inherited breast cancer; germline mutations; BRCA1; BRCA2; genetic testing; risk assessment; preventive strategies; targeted therapy; personalized medicine; genetic counseling

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Developing Genomics and Computational Approaches

edited by

Abedalrhman Alkhateeb

submission deadline 25 Nov 2025 | Viewed by 45 | Submission Open

Keywords: genomics; computational biology; bioinformatics; machine learning; artificial intelligence (AI); next-generation sequencing (NGS); precision medicine; multi-omics integration; CRISPR-based engineering; single-cell genomics; ethical; legal; and social implications (ELSI); translational genomics; biomedical prediction models; network biology

(This special issue belongs to the Section Technologies and Resources for Genetics)

Genetic Diagnosis and Therapeutics of Eye Diseases

edited by

Suzana Konjevoda

and

Snježana Kaštelan

submission deadline 25 Nov 2025 | Viewed by 42 | Submission Open

Keywords: genetic eye diseases; inherited retinal disorders; ophthalmic genetics; gene therapy; genetic diagnosis; retinitis pigmentosa; leber congenital amaurosis; personalised medicine; ocular therapeutics; genomic medicine; molecular diagnostics; precision ophthalmology

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Host Genetics and Pathogens in One Health Context

edited by

Nathalie Bissonnette

submission deadline 25 Nov 2025 | Viewed by 35 | Submission Open

Keywords: One Health; farm animals; disease resistance; antimicrobial resistance

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic Mechanisms of Plant Resistance to Biotic Stress

edited by

Zhuo Chen

submission deadline 25 Nov 2025 | Viewed by 33 | Submission Open

Keywords: plant diseases; biotic stress; resistance genes; genetics; genomics; plant hosts

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetics of Nerve Regeneration

edited by

Zhao-Qian Teng

and

Changmei Liu

submission deadline 25 Nov 2025 | Viewed by 25 | Submission Open

Keywords: nerve regeneration; neurodegeneration; neuroinflammation; metabolism; biomaterials; gene therapy; nerve repair; organoid

(This special issue belongs to the Section Neurogenomics)

The CranioFacial Biology Group at the University of Adelaide Collection: Genetic, Epigenetic and Environmental Factors in Complex Adaptive Systems, Multilayer Complex Interactive Networks, and Multiple Models During Oral Development

edited by

Alan H. Brook

and Matthew Brook O'Donnell

submission deadline 5 Dec 2025 | 1 articles | Viewed by 1636 | Submission Open

Keywords: oral development; genetics; epigenetics; complex adaptive systems; multilayer complex interactive networks; multiple models

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics of Neuromuscular and Metabolic Diseases

edited by Micheal Palladino and

Claudia Ricci

submission deadline 5 Dec 2025 | Viewed by 56 | Submission Open

Keywords: neurogenetics; metabolism; genetic models; biochemistry; therapy development; rare and ultra-rare genetic diseases

(This special issue belongs to the Section Neurogenomics)

Genetics and Genomics of Lung Diseases

edited by Jun Yang

submission deadline 10 Dec 2025 | Viewed by 87 | Submission Open

Keywords: lung diseases ; transcriptomics ; epigenetics ; gene– environment interaction ; functional genomics ; multi-omics integration

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Biomarkers in Cancer: From Discovery to Clinical Application

edited by

Evangelos Koustas

submission deadline 10 Dec 2025 | Viewed by 50 | Submission Open

Keywords: cancer; tumor biology; biomarkers; cancer therapy; targeted therapy

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Insights into the Genomic and Genetic Basis of Cardiovascular Disease

edited by Marzia de Biasio and

Donato Gemmati

submission deadline 10 Dec 2025 | Viewed by 50 | Submission Open

Keywords: recurrent idiopathic pericarditis and perimyocarditis; spontaneous coronary dissection; sudden idiopathic cardiac death; idiopathic atrial fibrillation; cardio-oncology and cardio toxicity of anti anti-cancer drugs

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Plant Genetics, Evolution, Cytogenetics and Cytogenomics for Biodiversity Conservation

edited by

Eric Javier Martínez

Ana Isabel Honfi

and

Anna Reutemann

submission deadline 15 Dec 2025 | 1 articles | Viewed by 898 | Submission Open

Keywords: plant conservation; cytogenetics; cytogenomics; plant evolution; population genetics; genome evolution; chromosomal variation; polyploidy; biodiversity; genomic resources

(This special issue belongs to the Section Plant Genetics and Genomics)

Research on Molecular Mechanisms of DNA Damage

edited by

Judith Miné-Hattab

submission deadline 15 Dec 2025 | Viewed by 165 | Submission Open

Keywords: molecular and structure biology of DNA repair; chromatin dynamics during DNA repair; 3D genome organization in repair mechanisms; liquid– liquid phase separation; mechanobiology and DNA repair; inhibitors of DNA damage proteins for cancer therapy; link between DNA damage and neurological diseases

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic and Molecular Insights into Cardiovascular Disease: From Mechanisms to Precision Medicine

edited by

Lingfeng Luo

and

Laurent Metzinger

submission deadline 15 Dec 2025 | Viewed by 107 | Submission Open

Keywords: cardiovascular disease; genetic variants; precision medicine; epigenetics; non-coding RNAs; polygenic risk scores; mendelian randomization; biomarkers; genome-wide association studies (GWASs); molecular mechanisms

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Molecular Genetics of Stress Response in Crops

edited by Jie Zhan

submission deadline 15 Dec 2025 | Viewed by 58 | Submission Open

Keywords: crop; abiotic stresses; protein translation; regulation; molecular mechanism; plant hormones

(This special issue belongs to the Section Plant Genetics and Genomics)

Advances in Cattle Genetics, Genomics and Breeding: From Molecular Insights to Sustainable Production

edited by

Hinayah Rojas De Oliveira

submission deadline 15 Dec 2025 | Viewed by 47 | Submission Open

Keywords: bovine; Bos taurus taurus; Bos taurus indicus; genomic selection; GWAS; multi-omics; gene editing; breeding strategies; reproductive technologies; genetic diversity; adaptation genetics; disease resistance; epigenetics; climate resilience; sustainable production; precision livestock farming

(This special issue belongs to the Section Animal Genetics and Genomics)

Application of Molecular or Genetic Markers in Liquid Biopsy for Urogenital Cancers

edited by

Guorong Li

submission deadline 15 Dec 2025 | Viewed by 26 | Submission Open

Keywords: liquid biopsy; extracellular vesicle; exosome; biotechnology; precision medicine/personalized medicine; diagnosis/screening; urogenital cancer

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetics and Epidemiology of Parasites

edited by

Joanna Da̧browska

submission deadline 15 Dec 2025 | Viewed by 16 | Submission Open

Keywords: parasite genetics; parasite genomics; WGS; molecular epidemiology; zoonoses; virulence and pathogenesis; transmission dynamics; genetic diversity

(This special issue belongs to the Section Microbial Genetics and Genomics)

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