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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetic Mechanisms of Obesity

edited by

Thangiah Geetha

submission deadline 25 Mar 2026 | Viewed by 197 | Submission Open

Keywords: obesity; genetic mechanisms; epigenetics; DNA methylation; genome-wide association studies; multi-omics; transcriptomics; foundtional genomics; gene– environment interactions; childhood obesity; energy metabolism; precision medicine; gut microbiota

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Chromatin Modifications and RNA-Based Regulation of Gene Expression

edited by Alonso Javier Pardal

submission deadline 25 Mar 2026 | Viewed by 83 | Submission Open

Keywords: chromatin modifications; RNA; gene expression; transcription; chromatin boundaries; RNA-binding proteins

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetics and Genomics of Aging and Longevity, Pathways and Response to Nutrients in Mammals and Simple Model Organisms

edited by

Mario G. Mirisola

submission deadline 30 Mar 2026 | Viewed by 249 | Submission Open

Keywords: nutrigenetics; nutrigenomics; signal transduction

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Application of CRISPR/Cas9 Technology in Insects

edited by

Sanyuan Ma

submission deadline 31 Mar 2026 | Viewed by 174 | Submission Open

Keywords: genome editing; gene targeting; CRISPR/Cas9; insect genetics; pest control; disease vector control; gene drive; off-target effects; delivery systems; ecological impact; transgenic insects; functional genomics

(This special issue belongs to the Section Animal Genetics and Genomics)

Novel Biomarkers of Neurodegenerative Diseases

edited by Arash Salardini

submission deadline 1 Apr 2026 | 1 articles | Viewed by 1269 | Submission Open

Keywords: neurodegenerative diseases; biomarker discovery; Alzheimer's disease; Parkinson's disease; precision medicine; machine learning

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics of Neuropsychiatric Disorders

edited by Melloni Cook and Kristin Hamre

submission deadline 5 Apr 2026 | 8 articles | Viewed by 11357 | Submission Open

Keywords: major depressive disorder; schizophrenia; post-traumatic stress disorder; addiction; alcohol; drugs; anxiety disorder; stress-related disorders; genes; epigenetics; mRNA; optogenetics; miRNA; causal variant

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genes and Gene Therapies in Chronic Renal Disease

edited by Thomas Kitzler

submission deadline 5 Apr 2026 | 3 articles | Viewed by 6279 | Submission Open

Keywords: chronic renal disease; personalized medicine; exome and genome sequencing; nephrogenetics; genetic kidney disease; small molecules; mRNA therapies; gene editing; gene delivery

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic and Epigenetic Factors for Autoimmune Diseases

edited by

Ulises De La Cruz-Mosso

submission deadline 5 Apr 2026 | 2 articles | Viewed by 2224 | Submission Open

Keywords: single nucleotide variants; polymorphism; mutations; microRNAs; HLA genes; cytokine gene; DNA methylation; rheumatoid arthritis; systemic lupus erythematosus; exposome

(This special issue belongs to the Section Epigenomics)

Conservation Genetics of Birds

edited by Robert Rutkowski

submission deadline 6 Apr 2026 | Viewed by 178 | Submission Open

Keywords: conservation genetics; birds; aves; endangered species; molecular markers; genetic diversity; genetic distance; isolated populations; non-invasive sampling; genetic monitoring; reintroduction; inbreeding; outbreeding; evolutionary significant units; management unit

(This special issue belongs to the Section Animal Genetics and Genomics)

Next-Generation Sequencing in Rare Genetic Diseases

edited by

Edoardo Errichiello

and

Paola Dimartino

submission deadline 10 Apr 2026 | 2 articles | Viewed by 1329 | Submission Open

Keywords: rare genetic diseases; next-generation sequencing; bioinformatics; multiomics data; artificial intelligence; gene discovery; single nucleotide variants; structural variants

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Status and Perspectives of Fisheries Resources

edited by Wei Wang

submission deadline 10 Apr 2026 | 1 articles | Viewed by 698 | Submission Open

Keywords: population genetics; aquaculture breeding and biotechnology; fisheries resource conservation and sustainable utilization; fisheries resource management; genetic technology and methods; climate change and genetic responses

(This special issue belongs to the Section Animal Genetics and Genomics)

Advances in Genomics and Epigenetics of Hearing Loss

edited by Alessandro Castiglione

submission deadline 10 Apr 2026 | Viewed by 310 | Submission Open

Keywords: genetics; hearing loss; inner ear; epigenetics; auditory system

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Coordinating Regulation of Gene Expression in Cardiovascular Disease

edited by

Nirmal Parajuli

submission deadline 10 Apr 2026 | Viewed by 292 | Submission Open

Keywords: microRNA; oxidative stress; cardiovascular disease; chronic obstructive pulmonary disease (COPD); pulmonary hypertension; gene regulation; inflammation; reactive oxygen species (ROS); molecular biomarkers; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Progress and Applications of Sequencing Technologies

edited by

Domenico Giosa

and Maria Papale

submission deadline 10 Apr 2026 | Viewed by 232 | Submission Open

Keywords: genomics; transcriptomics; epigenomics; metagenomics; bioinformatics; data analysis

(This special issue belongs to the Section Technologies and Resources for Genetics)

Genetic Insights and Molecular Pathways in Alzheimer's Disease: Unveiling the Complexity of Neurodegeneration

edited by Marta Rusek and

Alessandro Romano

submission deadline 10 Apr 2026 | Viewed by 176 | Submission Open

Keywords: Alzheimer’ s disease; neurodegeneration; amyloid-β pathology; tau pathology; APOE ε 4; APP; PSEN1; PSEN2; GWAS; neuroinflammation; mitochondrial dysfunction; oxidative stress; proteostasis; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics in Canines: From Evolution to Conservation

edited by

Marco Galaverni

and

Romolo Caniglia

submission deadline 15 Apr 2026 | 4 articles | Viewed by 17970 | Submission Open

Keywords: Canis lupus; genetics; genomics; conservation; evolution; adaptation; hybridization

(This special issue belongs to the Section Animal Genetics and Genomics)

Advances in Human Reproductive and Prenatal Genetics

edited by Edith Said

submission deadline 15 Apr 2026 | 1 articles | Viewed by 701 | Submission Open

Keywords: reproductive genetics; female infertility; male infertility; recurrent pregnancy loss; preconception genetic testing; pre-implantation genetic testing; prenatal genetics; non-invasive prenatal testing; molecular genetics; cytogenetics; molecular cytogenetics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics in Thyroid Cancer

edited by

Tatjana Bogovic Crncic

and Tomislav Jukić

submission deadline 15 Apr 2026 | 1 articles | Viewed by 656 | Submission Open

Keywords: genetic mutations; thyroid cancer; molecular diagnostics; risk stratification; novel therapies; MAPK/PI3K-AKT signalling; radioiodine-refractory; redifferentiation therapeutic strategies; tumour genomic profiling; targeted therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic and Genomic Advances in Livestock

edited by Karel Vališ

submission deadline 15 Apr 2026 | Viewed by 350 | Submission Open

Keywords: NGS; SNP calling; bioinformatic tools; livestock phenotype; livestock welfare

(This special issue belongs to the Section Animal Genetics and Genomics)

Non-Coding RNAs in Osteoarthritis: From Epigenetic Regulation to Therapeutic Targets

edited by Ioanna Papathanasiou

submission deadline 15 Apr 2026 | Viewed by 276 | Submission Open

Keywords: osteoarthritis; microRNAs; long non-coding RNAs; circular RNAs; biomarkers; therapeutic strategies

(This special issue belongs to the Section RNA)

Genes, Genomes, and Systems Biology in Agriculture

edited by Nick Hudson and

Pâmela A. Alexandre

submission deadline 15 Apr 2026 | Viewed by 268 | Submission Open

Keywords: systems biology; modelling; omics technologies; big data; machine learning; genetics; genomics; transcriptomics; microbiome; metabolomics

(This special issue belongs to the Section Technologies and Resources for Genetics)

Genetic and Genomic Analysis of Inflammatory Bowel Disease

edited by Mario Gorenjak and

Gregor Jezernik

submission deadline 15 Apr 2026 | Viewed by 201 | Submission Open

Keywords: inflammatory bowel disease; crohn’ s disease; ulcerative colitis; genomics; transcriptomics; biologicals; small-molecule drugs

(This special issue belongs to the Section Molecular Genetics and Genomics)

From Genes to Systems: Genetic and Epigenetic Control of the Metastatic Cascade

edited by Eric Rahrmann

submission deadline 15 Apr 2026 | Viewed by 163 | Submission Open

Keywords: cancer metastasis; genetic alterations; epigenetic reprogramming; tumor heterogeneity; lineage plasticity; metastatic niche formation; dormancy; circulating tumor cells (CTCs); immune evasion; therapy resistance; tumor microenvironment

(This special issue belongs to the Section Epigenomics)

Advances in Forensic Genetics and DNA

edited by

Maria Saiz

submission deadline 20 Apr 2026 | 6 articles | Viewed by 7430 | Submission Open

Keywords: human identification; crime scene investigation; next generation sequencing; forensic investigative genetic genealogy; lineage markers; DNA methylation; disaster victim identification

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Function and Molecular Mechanism for Immune Responses in Human Diseases

edited by Zsofia Banlaki

submission deadline 20 Apr 2026 | 1 articles | Viewed by 827 | Submission Open

Keywords: leukocyte; cytokine; immune receptor; signal transduction; gene expression; antibody-antigen; major histocompatibility complex; complement system; inflammation

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Pharmacogenomics and Pharmacoepigenomics in Autoimmune Diseases: How Close We Are to Personalised Medicine

edited by

Yiannis Vasilopoulos

and

Ioannis S. Vizirianakis

submission deadline 20 Apr 2026 | Viewed by 626 | Submission Open

Keywords: pharmacogenomics; pharmacoepigenomics; drug efficacy; drug toxicity; molecular pharmacology; autoimmune diseases

(This special issue belongs to the Section Pharmacogenetics)

HTAAD: Unraveling the Molecular and Clinical Complexity of Heritable Thoracic Aortic Disease

edited by

Guglielmina Pepe

, Rossella Fattori,

Stefano Nistri

and Yskert von Kodolitsch

submission deadline 20 Apr 2026 | Viewed by 238 | Submission Open

Keywords: syndromic and non-syndromic HTAAD; Loeys– Dietz syndrome; Marfan syndrome; vascular Ehlers– Danlos syndrome; bicuspid aortic valve; genotype– phenotype correlation; next-generation sequencing (NGS) and omics technologies; extracellular matrix; TGF-β signaling pathway and smooth muscle cell contraction genes; iconodiagnostic

(This special issue belongs to the Section Genetic Diagnosis)

Genetic Insights into Aging and Age-Related Diseases

edited by Monica Sanchez-Contreras

submission deadline 20 Apr 2026 | Viewed by 219 | Submission Open

Keywords: somatic mutations; aging; genomic instability; DNA damage; neurodegeneration; cancer

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genomic and Molecular Landscapes of Cardiac Remodeling and Heart Failure

edited by Dorota Ciołczyk-Wierzbicka

submission deadline 20 Apr 2026 | Viewed by 164 | Submission Open

Keywords: heart failure; genomics; transcriptomics; epigenetics/chromatin remodeling; non-coding RNAs; myocardial fibrosis; cardiac regeneration; multi-omics & AI-driven bioinformatics; precision cardiology; translational therapeutics

(This special issue belongs to the Section Genetic Diagnosis)

Genetic and Molecular Mechanisms in Animal Reproduction

edited by

Xianfeng Yu

submission deadline 20 Apr 2026 | Viewed by 142 | Submission Open

Keywords: gamete; embryo; gene regulation; epigenetics; cloning; IVP; ET

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic Diagnosis and Therapeutics of Eye Diseases

edited by

Suzana Konjevoda

and

Snježana Kaštelan

submission deadline 25 Apr 2026 | 3 articles | Viewed by 2342 | Submission Open

Keywords: genetic eye diseases; inherited retinal disorders; ophthalmic genetics; gene therapy; genetic diagnosis; retinitis pigmentosa; leber congenital amaurosis; personalised medicine; ocular therapeutics; genomic medicine; molecular diagnostics; precision ophthalmology

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Application of Genome-Wide Association Studies in Rare Diseases Research

edited by Menglu Liang and

Andrzej Ciechanowicz

submission deadline 25 Apr 2026 | 3 articles | Viewed by 2066 | Submission Open

Keywords: rare disease genetics; statistical methods; genomic association; small sample inference; polygenic risk scores; cross-ancestry GWAS; gene– gene interaction; gene– environment interaction; disease biomarkers; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics of Neuromuscular and Metabolic Diseases

edited by Micheal Palladino and

Claudia Ricci

submission deadline 25 Apr 2026 | 1 articles | Viewed by 1906 | Submission Open

Keywords: neurogenetics; metabolism; genetic models; biochemistry; therapy development; rare and ultra-rare genetic diseases

(This special issue belongs to the Section Neurogenomics)

Genetic Mechanisms of Synaptic Plasticity in Neuropsychiatric Disorders

edited by Lace Riggs

submission deadline 25 Apr 2026 | Viewed by 257 | Submission Open

Keywords: synaptic plasticity; neuropsychiatric disorders; autism spectrum disorder; schizophrenia; depression; epigenetic regulation; synaptic signaling; circuit dysfunction; gene– circuit interactions; molecular neuroscience; translational neurogenetics; epigenetics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

The Origin and Evolution of Genetic Code

edited by

Kenji Ikehara

submission deadline 25 Apr 2026 | Viewed by 178 | Submission Open

Keywords: origin of the genetic code; evolution of the genetic code; origin of gene; evolution of gene; origin of protein; evolution of protein; origin of life; evolution of life

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Mechanisms and Functional Insights in Microbiome Research

edited by

Tsute Chen

submission deadline 25 Apr 2026 | Viewed by 167 | Submission Open

Keywords: microbiome; marker genes; genomics; meta-genomics; meta-transcriptomics; proteomics; meta-proteomics; metabolomics; functional microbiome; microbiome-host interaction; microbiome-environment interaction; genetic mechanism

(This special issue belongs to the Section Microbial Genetics and Genomics)

Linking Phenotypic and Molecular Evolution: Mechanisms and Models

edited by Wen Wei

submission deadline 25 Apr 2026 | Viewed by 150 | Submission Open

Keywords: genomic and phenotypic evolution; adaptive evolution; selection and genetic drift; genotype– phenotype– fitness landscape; accumulation of mutations; evolvability of complex traits; molecular evolution drivers; transcriptomic agaianst protein-coding evolution; experimental evolution

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Advancing Crop Quality with Genomics, Genetics and Biotechnology

edited by

Xiquan Gao

and

José A. Mercado

submission deadline 25 Apr 2026 | Viewed by 138 | Submission Open

Keywords: crop quality; high throughput phenotyping; genome editing; genomic selection; nutritional quality; postharvest traits; precision breeding

(This special issue belongs to the Section Plant Genetics and Genomics)

Gene-Regulated Signaling Pathways in Cancer

edited by Alexander Damalas

submission deadline 25 Apr 2026 | Viewed by 133 | Submission Open

Keywords: caveolin-1 (CAV1); caveolae; Ras; EMT; invasion; MAPK; PI3K-Akt; membrane curvature (MC)

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genomics and Evolution of Plant Pathogenic Fungi

edited by Shuming Luo

submission deadline 25 Apr 2026 | Viewed by 102 | Submission Open

Keywords: fungi; virulence mutation; genomic characterization; gene sequencing; population genomics; comparative phylogenetic analysis; genetics and breeding

(This special issue belongs to the Section Microbial Genetics and Genomics)

Genomic Data Analysis in Human Health and Disease

edited by Ighli Di Bari and

Zhaohui S. Qin

submission deadline 27 Apr 2026 | Viewed by 361 | Submission Open

Keywords: protein modeling and structure-function prediction; variant pathogenicity prediction tools; functional annotation of genetic variants; machine learning in genomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Diagnosis, Management and Therapy of Rare Diseases

edited by Giorgia Girotto

submission deadline 30 Apr 2026 | 1 articles | Viewed by 709 | Submission Open

Keywords: rare and ultrarare genetic diseases; genetic mechanisms; gene-tailored management; personalized therapeutic approaches

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics of Intracerebral Hemorrhage

edited by Marialuisa Zedde and Rosario Pascarella

submission deadline 30 Apr 2026 | Viewed by 364 | Submission Open

Keywords: ICH; SVD; cavernous angioma; H-CAA; neuroimaging

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Selected Papers from the International Conference on Intelligent Biology and Medicine (ICIBM 2025)

edited by

Yan Guo

, Lianbo Yu,

Maciej Pietrzak

, Xinghua (Mindy) Shi and

Zhongming Zhao

submission deadline 1 May 2026 | Viewed by 111 | Submission Open

Keywords: functional and integrative genomics; next-generation sequencing; single-cell and spatial transcriptomics; epigenomics; systems biology; AI and machine learning in genomics; precision medicine; translational bioinformatics; metagenomics; computational tools for genomic data

Genetics of Nerve Regeneration

edited by

Zhao-Qian Teng

and

Changmei Liu

submission deadline 5 May 2026 | Viewed by 173 | Submission Open

Keywords: nerve regeneration; neurodegeneration; neuroinflammation; metabolism; biomaterials; gene therapy; nerve repair; organoid

(This special issue belongs to the Section Neurogenomics)

Epigenetic Insights into Stress-Related Disorders

edited by Lei Cao

submission deadline 5 May 2026 | Viewed by 173 | Submission Open

Keywords: stress; epigenetics; stress-related disorders; intervention; resilience

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Gene Therapy

edited by Ryan Butler

submission deadline 10 May 2026 | 1 articles | Viewed by 1699 | Submission Open

Keywords: gene therapy; rare diseases; viral vectors; RNA silencing; gene editing; methylation editing

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Emerging Topics in Population Genetics and Molecular Anthropology

edited by

Jelena Šarac

and Dubravka Havaš Auguštin

submission deadline 10 May 2026 | 2 articles | Viewed by 888 | Submission Open

Keywords: population genetics; molecular anthropology; archeogenetics; forensic genetics; impact of genetic diversity on human health; evolution; genome; phylogenetics

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Advances in Genetics of Skeletal Development

edited by André M Travessa,

Zhousheng Xiao

and

Dragan Primorac

submission deadline 10 May 2026 | 1 articles | Viewed by 737 | Submission Open

Keywords: skeletal development; skeletal dysplasias; clinical genetics; human genomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics of Neurodevelopmental Disorders, Pathogenesis, and Precision Therapies

edited by Andrea L . Gropman

submission deadline 10 May 2026 | Viewed by 261 | Submission Open

Keywords: biochemical genetics; brain imaging; fNIRs; metabolism; child neurology; developmental disorders

(This special issue belongs to the Section Neurogenomics)

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