Genomics and Genetics of Cardiovascular Diseases

Dear Colleagues,

The development of next-generation sequencing techniques has allowed us to make incredible progress in understanding the genetic etiologies of cardiovascular diseases over the past few decades. However, the number of different genes and genetic variants implicated in cardiovascular diseases such as cardiomyopathies, channelopathies, arrhythmias, and lipid disorders continues to increase. In addition, the complexity of the polygenic architectures of these diseases has yet to be untangled, leading to novel challenges in the interpretation of this vast data and clinical/translational applicability. Recent efforts to organize diverse large-scale populations linking genetic sequencing to longitudinal clinical data through biobanks and other large cohort studies have begun to shed light on these challenges in -omics research and the implementation of precision medicine for cardiovascular diseases. Paired with novel animal and cell culture models, these types of advances in genomics and bioinformatics have the potential to further our understanding of the genetic bases of cardiovascular diseases, nominate novel therapeutic targets for intervention, and provide data-driven guidance for the implementation of precision medicine. In summary, the aim of this Special Issue titled “Genomics and Genetics of Cardiovascular Diseases” is to present state-of-the-art review articles summarizing recent trends within the scientific community, as well as to publish original articles providing novel insights into the genetic and/or genomic aspects of cardiovascular diseases. Especially, studies with a focus on translational research and those based on large-scale studies linking genetic sequencing to clinical data are highly welcome.

You may choose our Joint Special Issue in Cardiogenetics.

Dr. Joseph Park
Guest Editor

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• cardiovascular genetics/genomics
• large-scale biobank and cohort studies
• cardiomyopathies
• channelopathies/arrhythmias
• heart failure
• lipid disorders