Advances in Hybrid Gels Films

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Processing and Engineering".

Deadline for manuscript submissions: closed (20 February 2024) | Viewed by 4425

Special Issue Editors

Guangdong Biomaterials Engineering Technology Research Center, Institute of Biological and Medical Engineering, Guangdong Academy of Sciences, Guangzhou 510316, China
Interests: wastewater treatment; hydrogels; packaging film; biodegradable plastics
College of Light Industry and Food Engineering, Guangxi Key Laboratory of Clean Pulp and Papermaking and Pollution Control, Guangxi University, Nanning, Guangxi
Interests: cellulose; microgel; pickering emulsion; microcapsules; porous composite

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Guest Editor
School of Materials Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, China
Interests: antimicrobial hydrogels; reactive extrusion; surface and interphase treatment; functional polymer materials; bio-based or bio-degradable materials

Special Issue Information

Dear Colleagues,

Recently, the replacement of fossil-based techniques for various fields such as pollution control, biomedicine, etc., using green materials or approaches has emerged as a key research hotspot. Bio-based gels films or composites are the most appropriate candidates for this due to the biocompatibility, low-cost, and the dominant barrier properties, etc. The hybrid gels consisting of nanofillers and the functional biopolymers provide another approach for synthesizing functional materials. The high dispersion of the nanomaterials in gels dramatically increases the mechanical, barrier, antimicrobial, and antioxidant properties of the films and composites.

Thus, this Special Issue of Gels, entitled “Advances in Hybrid Gels Films”, aims to collect up-to-date advances in the broad subject area of hybrid gels films. Studies, research articles and reviews on gel-based films, gel-based composites, gel with nano or macro fillers, as well as novel hybrid and functional gels are welcome.

Dr. Yuan Li
Dr. Peng Lu
Dr. Yong Guan
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gel film
  • hybrid gels
  • functional additives
  • nano or macro fillers
  • drug release

Published Papers (3 papers)

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Research

14 pages, 2048 KiB  
Article
Comparison of Hydroxypropyl Methylcellulose and Alginate Gel Films with Meloxicam as Fast Orodispersible Drug Delivery
by Barbara Jadach, Martyna Misek and Jan Ferlak
Gels 2023, 9(9), 687; https://doi.org/10.3390/gels9090687 - 25 Aug 2023
Cited by 1 | Viewed by 1333
Abstract
The aim of the study was the preparation and comparison of two types of orodispersible gel films (ODF) by the solvent casting method. Natural polymers: sodium alginate (ALG) or hydroxypropyl methylcellulose (HPMC) were used as the gel film formers, and Kollidon or microcrystalline [...] Read more.
The aim of the study was the preparation and comparison of two types of orodispersible gel films (ODF) by the solvent casting method. Natural polymers: sodium alginate (ALG) or hydroxypropyl methylcellulose (HPMC) were used as the gel film formers, and Kollidon or microcrystalline cellulose was used as the disintegrant. Meloxicam (MLX), the drug used to treat rheumatic diseases for children and adults, was proposed as the active pharmaceutical ingredient (API). The influence of the polymer and disintegrant on the properties of ODF was investigated. The evaluation of prepared gel films was based on appearance description, mass uniformity measurement, disintegration time, API content, film wettability, and water content. Also, the dissolution test was prepared in a basket apparatus using artificial salvia (pH = 6.8) as the medium. The obtained API release profiles were analyzed for the similarity factors (f2) with the DDSolver software. The results showed that independently of the polymer or disintegrant, using the solvent casting method, gel films have a similar appearance and active substance content close to the theoretical value and water content of less than 10%. Only the type of polymer influences the release profiles of MLX. However, the disintegration time was longer than 30 s, which makes the films non-fast-dissolving drug delivery systems. This means that for the ODF system, further evaluation is required, and some changes in the composition of the film have to be done. Full article
(This article belongs to the Special Issue Advances in Hybrid Gels Films)
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19 pages, 6124 KiB  
Article
Carboxymethyl Chitosan/Sodium Alginate/Chitosan Quaternary Ammonium Salt Composite Hydrogel Supported 3J for the Treatment of Oral Ulcer
by Tao Lin, Dandan Chen, Yan Geng, Jiayu Li, Yanghui Ou, Zhijun Zeng, Canqiang Yin, Xudong Qian, Xiang Qiu, Gang Li, Yali Zhang, Wen Guan, Mengjie Li, Xiaojia Cai, Jiaqiang Wu, Wen-Hua Chen, Yan-Qing Guan and Hongliang Yao
Gels 2023, 9(8), 659; https://doi.org/10.3390/gels9080659 - 16 Aug 2023
Viewed by 1408
Abstract
Oral ulcer is a common inflammatory disease of oral mucosa, causing severe burning pain and great inconvenience to daily life. In this study, compound 3J with anti-inflammatory activity was synthesized beforehand. Following that, an intelligent composite hydrogel supported 3J was designed with sodium [...] Read more.
Oral ulcer is a common inflammatory disease of oral mucosa, causing severe burning pain and great inconvenience to daily life. In this study, compound 3J with anti-inflammatory activity was synthesized beforehand. Following that, an intelligent composite hydrogel supported 3J was designed with sodium alginate, carboxymethyl chitosan, and chitosan quaternary ammonium salt as the skeleton, and its therapeutic effect on the rat oral ulcer model was investigated. The results show that the composite hydrogel has a dense honeycomb structure, which is conducive to drug loading and wound ventilation, and has biodegradability. It has certain antibacterial effects and good anti-inflammatory activity. When loaded with 3J, it reduced levels of TNF-α and IL-6 in inflammatory cells by up to 50.0%. It has excellent swelling and water retention properties, with a swelling rate of up to 765.0% in a pH 8.5 environment. The existence of a large number of quaternary ammonium groups, carboxyl groups, and hydroxyl groups makes it show obvious differences in swelling in different pH environments, which proves that it has double pH sensitivity. It is beneficial to adapt to the highly dynamic changes of the oral environment. Compared with single hydrogel or drug treatment, the drug-loaded hydrogel has a better effect on the treatment of oral ulcers. Full article
(This article belongs to the Special Issue Advances in Hybrid Gels Films)
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19 pages, 8913 KiB  
Article
Multifunctional Oxidized Dextran Cross-Linked Alkylated Chitosan/Drug-Loaded and Silver-Doped Mesoporous Bioactive Glass Cryogel for Hemostasis of Noncompressible Wounds
by Dong Lei, Jing Zhao, Chenhui Zhu, Min Jiang, Pei Ma, Yu Mi and Daidi Fan
Gels 2023, 9(6), 455; https://doi.org/10.3390/gels9060455 - 01 Jun 2023
Cited by 3 | Viewed by 1268
Abstract
Noncompressible wounds resulting from accidents and gunshots are typically associated with excessive bleeding, slow wound healing, and bacterial infection. Shape-memory cryogel presents great potential in controlling the hemorrhaging of noncompressible wounds. In this research, a shape-memory cryogel was prepared using a Schiff base [...] Read more.
Noncompressible wounds resulting from accidents and gunshots are typically associated with excessive bleeding, slow wound healing, and bacterial infection. Shape-memory cryogel presents great potential in controlling the hemorrhaging of noncompressible wounds. In this research, a shape-memory cryogel was prepared using a Schiff base reaction between alkylated chitosan (AC) and oxidized dextran (ODex) and then incorporated with a drug-laden and silver-doped mesoporous bioactive glass (MBG). Hydrophobic alkyl chains enhanced the hemostatic and antimicrobial efficiency of the chitosan, forming blood clots in the anticoagulated condition, and expanding the application scenarios of chitosan-based hemostats. The silver-doped MBG activated the endogenous coagulation pathway by releasing Ca2+ and prevented infection through the release of Ag+. In addition, the proangiogenic desferrioxamine (DFO) in the mesopores of the MBG was released gradually to promote wound healing. We demonstrated that AC/ODex/Ag-MBG DFO(AOM) cryogels exhibited excellent blood absorption capability, facilitating rapid shape recovery. It provided a higher hemostatic capacity in normal and heparin-treated rat-liver perforation-wound models than gelatin sponges and gauze. The AOM gels simultaneously promoted infiltration, angiogenesis, and tissue integration of liver parenchymal cells. Furthermore, the composite cryogel exhibited antibacterial activity against Staphylococcus aureus and Escherichia coli. Thus, AOM gels show great promise for clinical translation in treating lethal, noncompressible bleeding and the promotion of wound healing. Full article
(This article belongs to the Special Issue Advances in Hybrid Gels Films)
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