Novel Gels for 3D Bioprinting in Tissue Engineering

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 873

Special Issue Editors


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Guest Editor
Instituto de Tecnologías Emergentes y Ciencias Aplicadas (ITECA), Escuela de Ciencia y Tecnología (ECyT), Universidad Nacional de San Martín, CONICET, San Martín, Buenos Aires B1650, Argentina
Interests: rheology; mechanical properties; polymers; bioprinting; resorbable biomaterials

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Guest Editor
1. Facultad de Farmacia y Bioquímica, Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad de Buenos Aires, Buenos Aires 1113, Argentina
2. Instituto de Ciências Biológicas (ICB), Universidade Federal do Rio Grande—FURG, Rio Grande 96203-900, RS, Brazil
Interests: biomaterials; nanomaterials; 3D printing; tissue engineering; bioinks
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Special Issue Information

Dear Colleagues,

Because of their distinct physicochemical characteristics, biocompatibility, and capacity to replicate the extracellular matrix, gels have become a fundamental component of tissue engineering, especially in the field of 3D bioprinting. As the field of 3D bioprinting advances, the development of novel gels with tailored mechanical, rheological, and biological properties is critical to overcoming current limitations and enabling the fabrication of complex, functional tissues that support cell growth, differentiation, and tissue regeneration.

This Special Issue is dedicated to exploring the latest advancements in the design, synthesis, and application of novel gels for 3D bioprinting in tissue engineering. We invite contributions that address the development of innovative gel-based bioinks, their characterization, and their evaluation in preclinical and clinical settings. Topics of interest include, but are not limited to, the following:

  • Design and synthesis of novel gel materials for 3D bioprinting applications.
  • Advanced bioinks with enhanced printability, mechanical properties, and biocompatibility.
  • Stimuli-responsive gels for dynamic and adaptive tissue engineering constructs.
  • Multifunctional gels incorporating bioactive molecules, growth factors, or nanoparticles.
  • Strategies to improve gel stability, degradation kinetics, and integration with host tissues.
  • In vitro and in vivo evaluation of 3D-bioprinted gel-based constructs.
  • Computational modeling and optimization of gel properties for 3D bioprinting.
  • Challenges and opportunities in translating gel-based bioprinting technologies to clinical applications.

We welcome original research articles and perspectives that highlight cutting-edge developments in this rapidly evolving field. By bringing together diverse expertise, this Special Issue aims to foster collaboration and innovation, ultimately advancing the development of next-generation gels for 3D bioprinting and their application in tissue engineering.

We look forward to receiving your contributions.

Prof. Dr. Élida B. Hermida
Prof. Dr. Martin Federico Desimone
Guest Editors

Manuscript Submission Information

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Keywords

  • bioinks
  • bioprinting
  • biofabrication
  • printability
  • stimuli-responsive gels
  • rheology
  • tissue-engineering
  • 3D bioprinting

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Published Papers (2 papers)

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Research

33 pages, 15465 KB  
Article
Effect of Phosphate Phase Incorporation on 3D-Printed Hydrogel Scaffolds: Towards Customizable Bone Graft Materials
by Andreea Trifan, Eduard Liciu, Andrei-Silviu Nedelcu, Mihai Dragomir, Doru-Daniel Cristea, Ciprian-Ștefan Mateescu, David-Andrei Nițulescu, Cătălina-Ana-Maria Cîrstea, Adela Banciu, Gabriela Toader, Aurel Diacon and Cristina Busuioc
Gels 2025, 11(8), 665; https://doi.org/10.3390/gels11080665 - 20 Aug 2025
Viewed by 197
Abstract
Bone defects remain a significant clinical challenge, creating a severe need for advanced biomaterials for tissue regeneration. This study addresses this issue by developing 3D-printed composite hydrogels containing alginate, gelatine, and resorbable calcium phosphates (monetite and brushite) for bone tissue engineering. The scaffolds [...] Read more.
Bone defects remain a significant clinical challenge, creating a severe need for advanced biomaterials for tissue regeneration. This study addresses this issue by developing 3D-printed composite hydrogels containing alginate, gelatine, and resorbable calcium phosphates (monetite and brushite) for bone tissue engineering. The scaffolds were fabricated using extrusion-based 3D printing and evaluated for their morphology, porosity, mechanical strength, swelling, degradation, and in vitro mineralization, while their cytocompatibility was assessed using LIVE/DEAD cell viability assays. The key findings demonstrate that calcium phosphate incorporation enhanced the mechanical stability by 15–25% compared to the controls, and mineral deposition increased significantly in the composite scaffolds. The developed hydrogels are bioactive and represent promising, customizable scaffolds for bone regeneration. These results support their further investigation as viable alternatives to traditional bone grafts for clinical bone tissue engineering applications. Full article
(This article belongs to the Special Issue Novel Gels for 3D Bioprinting in Tissue Engineering)
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15 pages, 11614 KB  
Article
Effect of 3D Printing Parameters on the Transparency of Medical Hydrogels for Corneal Stroma Fabrication
by Qiang Gao, Kaicheng Yu, Youyun Shang, Zexue Lin, Min Zhu, Lihua Lu, Tao Jiang and Peng Zhang
Gels 2025, 11(7), 528; https://doi.org/10.3390/gels11070528 - 8 Jul 2025
Viewed by 439
Abstract
Medical hydrogels represent a promising solution for the treatment of corneal diseases and trauma, offering potential to address the shortage of donor corneas. To meet the functional requirements of artificial corneas in tissue engineering, it is crucial to fabricate biomimetic structures with high [...] Read more.
Medical hydrogels represent a promising solution for the treatment of corneal diseases and trauma, offering potential to address the shortage of donor corneas. To meet the functional requirements of artificial corneas in tissue engineering, it is crucial to fabricate biomimetic structures with high optical transparency using 3D printing techniques. As fiber alignment during the printing process has a pronounced impact on light transmittance, precise control of the printing parameters is essential. This study focuses on the experimental optimization of 3D printing conditions for hydrogel materials to improve their physical properties, particularly optical clarity, thereby enhancing their suitability for artificial corneal applications. Collagen derived from bovine Achilles tendons was chosen due to its excellent printability. A series of controlled experiments were conducted to systematically investigate the influence of key process parameters on hydrogel transparency. The findings enabled the identification of an optimized parameter set that significantly improved the optical properties of the 3D-printed biomimetic corneal stroma. Additionally, cell seeding and culture assays confirmed the favorable biocompatibility of the developed material. Full article
(This article belongs to the Special Issue Novel Gels for 3D Bioprinting in Tissue Engineering)
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