Dietary Regulation of Oxidative Stress in Chronic Diseases

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Nutrition".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 1126

Special Issue Editors


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Guest Editor
Institute of Medical Research Yugoslavia Serbia, Belgade, Serbia
Interests: nutrition; polyphenols; fatty acids; redox status; metabolic syndrome

E-Mail Website
Guest Editor
Institute for Medical Research, University of Belgrade, Belgrade, Serbia
Interests: nutrition; phytochemicals; cardiovascular health; platelets; oxidative stress

Special Issue Information

Dear Colleagues,

Oxidative stress is a state of marked imbalance between the production of reactive oxygen and nitrogen species (ROS, RNS), from both endogenous and exogenous sources, and their removal by antioxidants. Although the origin of many chronic diseases can be multifactorial, oxidative stress is common to all of them. Oxidative stress contributes to the pathology of cardiovascular, renal, and lung diseases, neurological disorders, cancer, diabetes, psychiatric conditions, and ageing. On the other side, studies have indicated that regular consumption of fruits, vegetables, and other foods rich in antioxidants may lower the incidence and/or delay the onset of chronic diseases. Dietary antioxidants are food constituents that can prevent and ameliorate the deleterious effects of ROS and RNS on normal physiological functions. This Special Issue will highlight the existing evidence regarding different functional foods, nutritive and non-nutritive (bioactive) compounds and their health effects, with the focus on their impact on oxidative stress, as a common denominator of most chronic diseases.

Dr. Marija M. Takić
Dr. Nevena Kardum Vidović
Guest Editors

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Keywords

  • oxidative stress
  • dietary antioxidants
  • bioactive compounds
  • functional foods
  • non-communicable chronic diseases
  • human health
  • polyphenols
  • lipid peroxides
  • metabolic syndrome

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Published Papers (1 paper)

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Research

21 pages, 1788 KiB  
Article
The Phytochemical and Functional Characterization of the Aerial Parts of Artemisa alba Turra (Asteraceae) Grown in Romania
by Mădălina Țicolea, Raluca Maria Pop, Marcel Pârvu, Lia-Oxana Usatiuc, Ana Uifălean, Valeria Alvarez Brito, Eva Fischer-Fodor, Floricuța Ranga, Crina Claudia Rusu, Maria Crisan, Bianca Bosca, Florinela Adriana Cătoi and Alina Elena Pârvu
Foods 2025, 14(8), 1389; https://doi.org/10.3390/foods14081389 - 17 Apr 2025
Viewed by 355
Abstract
Artemisia alba Turra is a plant used in folk medicine. Due to its significant polymorphism, there are different chemotypes. This study aimed to characterize the specific chemotypes and evaluate the anti-inflammatory, antioxidant, and antiproliferative potential of an ethanol extract of A. alba Turra [...] Read more.
Artemisia alba Turra is a plant used in folk medicine. Due to its significant polymorphism, there are different chemotypes. This study aimed to characterize the specific chemotypes and evaluate the anti-inflammatory, antioxidant, and antiproliferative potential of an ethanol extract of A. alba Turra aerial parts prepared from plants harvested from the “Alexandru Borza” Botanical Garden, Cluj-Napoca, Romania. The extract phytochemical analysis performed by measuring total polyphenol content (3.4 ± 0.21 mgGAE/g d.w.), total polyphenolic flavonoids (147.12 ± 10.09 mg QE/100 g d.w.), and HPLC-ESI MS polyphenol profiles indicated that in the A. alba Tura extract from the hydroxycinnamic acids chlorogenic acid, caffeoyl tartaric acid, 3,4-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid, and 4,5-dicaffeoylquinic acid had and from the flavonols, isorhamnetin-rutinoside and rutin had the highest concentration. The extract exhibited good in vitro and in vivo antioxidant activity by reducing oxidants without significant effects on antioxidants. The anti-inflammatory effect tested on rat turpentine oil-induced inflammation was indicated by the reduction in NLRP3 inflammasome markers, NfkB-p65, IL-1β, IL-18, caspase-1, and gasdermin D. The extract had in vitro antiproliferative activity against ovarian tumor cell lines at concentrations from 12.5 to 50 μg/mL, and this mechanism was linked to MDR and NF-κB modulation. A. alba Turra had no liver toxicity and reduced kidney injury associated with inflammation. These findings indicated that this specific Romanian chemotype of A. alba Turra has antioxidant, anti-inflammatory, and antiproliferative properties with potential applications as tumor microenvironment-targeted therapy. Full article
(This article belongs to the Special Issue Dietary Regulation of Oxidative Stress in Chronic Diseases)
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