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Article

The Phytochemical and Functional Characterization of the Aerial Parts of Artemisa alba Turra (Asteraceae) Grown in Romania

by
Mădălina Țicolea
1,
Raluca Maria Pop
2,*,
Marcel Pârvu
3,
Lia-Oxana Usatiuc
1,
Ana Uifălean
1,
Valeria Alvarez Brito
4,
Eva Fischer-Fodor
5,
Floricuța Ranga
6,
Crina Claudia Rusu
7,8,
Maria Crisan
9,
Bianca Bosca
9,
Florinela Adriana Cătoi
1 and
Alina Elena Pârvu
1
1
Department of Morpho-Functional Sciences, Discipline of Pathophysiology, “Iuliu Haţieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
2
Department of Morpho-Functional Sciences, Discipline of Pharmacology, Toxicology and Clinical Pharmacology, “Iuliu Haţieganu” University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania
3
Department of Biology, Babes-Bolyai University, 400015 Cluj-Napoca, Romania
4
Faculty of Medicine, Autonomous University of Nuevo Leon, Monterrey 64460, Mexico
5
Tumor Biology Department, The Oncology Institute “I. Chiricuță”, 400015 Cluj-Napoca, Romania
6
Food Science and Technology, Department of Food Science, University of Agricultural Science and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania
7
Department of Nephrology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
8
“Mihai Manasia” Nephrology and Dialysis Clinic, County Emergency Clinical Hospital Cluj, 400347 Cluj-Napoca, Romania
9
Department of Morpho-Functional Sciences, Discipline of Histology, “Iuliu Haţieganu” University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
Foods 2025, 14(8), 1389; https://doi.org/10.3390/foods14081389
Submission received: 7 March 2025 / Revised: 9 April 2025 / Accepted: 14 April 2025 / Published: 17 April 2025
(This article belongs to the Special Issue Dietary Regulation of Oxidative Stress in Chronic Diseases)
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Abstract

Artemisia alba Turra is a plant used in folk medicine. Due to its significant polymorphism, there are different chemotypes. This study aimed to characterize the specific chemotypes and evaluate the anti-inflammatory, antioxidant, and antiproliferative potential of an ethanol extract of A. alba Turra aerial parts prepared from plants harvested from the “Alexandru Borza” Botanical Garden, Cluj-Napoca, Romania. The extract phytochemical analysis performed by measuring total polyphenol content (3.4 ± 0.21 mgGAE/g d.w.), total polyphenolic flavonoids (147.12 ± 10.09 mg QE/100 g d.w.), and HPLC-ESI MS polyphenol profiles indicated that in the A. alba Tura extract from the hydroxycinnamic acids chlorogenic acid, caffeoyl tartaric acid, 3,4-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid, and 4,5-dicaffeoylquinic acid had and from the flavonols, isorhamnetin-rutinoside and rutin had the highest concentration. The extract exhibited good in vitro and in vivo antioxidant activity by reducing oxidants without significant effects on antioxidants. The anti-inflammatory effect tested on rat turpentine oil-induced inflammation was indicated by the reduction in NLRP3 inflammasome markers, NfkB-p65, IL-1β, IL-18, caspase-1, and gasdermin D. The extract had in vitro antiproliferative activity against ovarian tumor cell lines at concentrations from 12.5 to 50 μg/mL, and this mechanism was linked to MDR and NF-κB modulation. A. alba Turra had no liver toxicity and reduced kidney injury associated with inflammation. These findings indicated that this specific Romanian chemotype of A. alba Turra has antioxidant, anti-inflammatory, and antiproliferative properties with potential applications as tumor microenvironment-targeted therapy.
Keywords: Artemisia alba Turra; phytochemistry; inflammation; oxidative stress; antiproliferative Artemisia alba Turra; phytochemistry; inflammation; oxidative stress; antiproliferative
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MDPI and ACS Style

Țicolea, M.; Pop, R.M.; Pârvu, M.; Usatiuc, L.-O.; Uifălean, A.; Brito, V.A.; Fischer-Fodor, E.; Ranga, F.; Rusu, C.C.; Crisan, M.; et al. The Phytochemical and Functional Characterization of the Aerial Parts of Artemisa alba Turra (Asteraceae) Grown in Romania. Foods 2025, 14, 1389. https://doi.org/10.3390/foods14081389

AMA Style

Țicolea M, Pop RM, Pârvu M, Usatiuc L-O, Uifălean A, Brito VA, Fischer-Fodor E, Ranga F, Rusu CC, Crisan M, et al. The Phytochemical and Functional Characterization of the Aerial Parts of Artemisa alba Turra (Asteraceae) Grown in Romania. Foods. 2025; 14(8):1389. https://doi.org/10.3390/foods14081389

Chicago/Turabian Style

Țicolea, Mădălina, Raluca Maria Pop, Marcel Pârvu, Lia-Oxana Usatiuc, Ana Uifălean, Valeria Alvarez Brito, Eva Fischer-Fodor, Floricuța Ranga, Crina Claudia Rusu, Maria Crisan, and et al. 2025. "The Phytochemical and Functional Characterization of the Aerial Parts of Artemisa alba Turra (Asteraceae) Grown in Romania" Foods 14, no. 8: 1389. https://doi.org/10.3390/foods14081389

APA Style

Țicolea, M., Pop, R. M., Pârvu, M., Usatiuc, L.-O., Uifălean, A., Brito, V. A., Fischer-Fodor, E., Ranga, F., Rusu, C. C., Crisan, M., Bosca, B., Cătoi, F. A., & Pârvu, A. E. (2025). The Phytochemical and Functional Characterization of the Aerial Parts of Artemisa alba Turra (Asteraceae) Grown in Romania. Foods, 14(8), 1389. https://doi.org/10.3390/foods14081389

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