Advanced and Intelligent Biomaterials for Precision Delivery of Food Bioactives: From Molecular Design to Fortification Efficacy

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Engineering and Technology".

Deadline for manuscript submissions: 13 November 2026 | Viewed by 726

Special Issue Editors


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Guest Editor
College of Food Science, Northeast Agricultural University, Harbin 150030, China
Interests: emulsion stability mechanisms; nutrient and probiotic encapsulation delivery; protein modification; functional foods
College of Food Engineering and Nutritional Engineering, China Agricultural University, Beijing 100083, China
Interests: self-assembly; nanofibril; plant-based proteins; controlled release; functional foods; emulsion
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Special Issue Information

Dear Colleagues,

Many bioactive substances from plants, animals, and microorganisms have attracted increasing attention from researchers due to the health benefits they provide the human body. However, their application in foods often faces multiple challenges, such as undesired sensory attributes, poor solubility, and poor physicochemical stability. While conventional encapsulation technologies address these issues, this Special Issue aims to pioneer a more fundamental and intelligent approach by focusing on the frontier of advanced biomaterial design as the engine for next-generation delivery solutions.

We seek to move beyond application reports to highlight how rational material innovation constructs programmable, high-performance carriers. This endeavor encompasses, but is not limited to, the following topics:

  1. Rational design and synthesis of novel, food-grade biomaterials (e.g., engineered proteins, structured polysaccharides, self-assembled architectures, upcycled biopolymers) with the development of functional foods and the integration of sustainable technologies.
  2. Stimuli-responsive and “smart” delivery systems whose release mechanisms are programmed at the material level to react to specific physiological or processing triggers.
  3. Multi-scale structural engineering of biomaterial-based carriers, linking their molecular/nano-/microstructure to enhanced stability, bioavailability, resistance to environmental stress, controlled release, and targeted delivery performance.
  4. Mechanistic insights into the interactions between advanced biomaterial carriers, bioactive compounds, and the human gastrointestinal tract to elucidate the pathways to improved efficacy.

This Special Issue will serve as a dedicated platform for research that places material science and engineering at the core of delivery innovation. We encourage the submission of high-quality original research articles and timely reviews that demonstrate how breakthroughs in advanced and intelligent biomaterials are driving the future of precision delivery and fortification in foods.

Dr. Jinju Cheng
Dr. Xing Li
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • intelligent delivery systems
  • bioavailability of advanced biomaterials
  • stimuli-responsive release
  • multi-scale structural design
  • bioactive ingredients
  • food fortification
  • interfacial engineering
  • functional foods

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Published Papers (1 paper)

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Research

15 pages, 1437 KB  
Article
Prebiotic-Empowered Probiotics with Gastrointestinal Stress Resistance for Enhanced Oral Therapy of Immunosuppression
by Xiaomin Chen, Huangxin Zhu, Zuwei Liu, Qianru Zhao, Ying Zhang, Yiqun Wan and Hao Wan
Foods 2026, 15(9), 1540; https://doi.org/10.3390/foods15091540 - 29 Apr 2026
Viewed by 443
Abstract
Oral probiotic-based therapy has emerged as a promising solution with multifaceted benefits for immunosuppression treatment. However, their widespread and clinical utility is severely limited by the poor viability of probiotics under harsh gastrointestinal conditions in the intestine. To address these challenges, a probiotic-based [...] Read more.
Oral probiotic-based therapy has emerged as a promising solution with multifaceted benefits for immunosuppression treatment. However, their widespread and clinical utility is severely limited by the poor viability of probiotics under harsh gastrointestinal conditions in the intestine. To address these challenges, a probiotic-based biohybrid (Lr@DGN) was bio-orthogonally fabricated by covalently anchoring the prebiotic β-glucan (GN) to the probiotic Limosilactobacillus reuteri (Lr). Upon oral administration, Lr@DGN colonized intestines with high survival rates, aided by gastrointestinal stress-shielding of GN, leading to immuno-enhancing effects through combining GN and live Lr. Consequently, in a Cy-induced immunosuppression mouse model, oral administration of Lr@DGN significantly mitigated body weight loss, restored the key immune organ indexes (thymus and spleen), ameliorated Cy-induced damage to the small intestine, enhanced the intestinal immune response, and elevated the serum levels of immunoglobulins IgG and IgA. By integrating the effects of a prebiotic shield and a live probiotic, this biohybrid system offers a promising and translatable approach for managing immunodeficiency and related disorders. Full article
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