Beneficial Effects of Phenolic Compounds on Gut Microbiota and Metabolic Syndrome

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Nutrition".

Deadline for manuscript submissions: closed (10 March 2022) | Viewed by 2598

Special Issue Editors


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Guest Editor
College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
Interests: polyphenols; structure-activity relationship; polyphenols and metabolic syndrome; obesity interventions; polyphenols and gut microbiota
Key Laboratory of Environment Correlative Food Science, College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
Interests: polyphenols; animal model; digestion
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Special Issue Information

Dear Colleagues,

Obesity and metabolic syndrome (MetS) represent one of the greatest health epidemics of the 21st century, with current medical strategies having limited efficacy, poor tolerance, and high cost. The gut microbiota is an important contributor to human health and has been implicated in the development of obesity and obesity-related diseases such as MetS. Dietary intervention has been proven to be a good strategy for improving chronic metabolic diseases, and polyphenols such as curcumin, anthocyanins, proanthocyanidin, and tea polyphenols have been found to prevent both obesity and improve MetS in humans and animal models. It has been proven that polyphenols exhibit their anti-obesity abilities partially by inhibiting the digestion and absorption of fat and glucose, by inhibiting adipogenesis, by altering microbiome populations, and so on. However, there are still many questions that need to be cleared. For example, what are the effects of microorganisms that colonize the human gut on the digestion and absorption of dietary polyphenols (PPs)? How do dietary polyphenols regulate gut microbiota? Additionally, work needs to be done on the mining and research of new dietary polyphenol resources. This Special Issue is therefore open to all contributions aimed at investigating the beneficial effects of phenolic compounds on gut microbiota and metabolic syndrome.

Prof. Dr. Chunmei Li
Dr. Kaikai Li
Guest Editors

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Keywords

  • polyphenols
  • metabolic syndrome
  • obesity
  • gut microbiota
  • dietary intervention
  • digestion and absorption

Published Papers (1 paper)

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Research

17 pages, 2647 KiB  
Article
Inhibitory Effects against Alpha-Amylase of an Enriched Polyphenol Extract from Pericarp of Mangosteen (Garcinia mangostana)
by Xiaofang Li, Haoze Chen, Yan Jia, Jinming Peng and Chunmei Li
Foods 2022, 11(7), 1001; https://doi.org/10.3390/foods11071001 - 29 Mar 2022
Cited by 4 | Viewed by 2167
Abstract
The pericarp of mangosteen, a by-product of the mangosteen, is rich in polyphenols. In this study, an efficient and environmentally friendly method for preparative enrichment of polyphenols from mangosteen pericarp (MPPs) was developed, and the inhibitory effects on starch digestion were also evaluated. [...] Read more.
The pericarp of mangosteen, a by-product of the mangosteen, is rich in polyphenols. In this study, an efficient and environmentally friendly method for preparative enrichment of polyphenols from mangosteen pericarp (MPPs) was developed, and the inhibitory effects on starch digestion were also evaluated. It was found that the optimal extract method of MPPs was at a solid to solvent ratio of 1:50 g/mL, pH of 2, and at 80 °C for 2 h. The IC50 of MPPs for α-amylase was 0.28 mg/mL. Based on the fluorescence quenching results, we presumed that MPPs could alter the natural structure of α-amylase, resulting in inhibitory activity on α-amylase. In addition, MPPs significantly reduced the blood glucose peak and AUC of glucose responses in rats after ingestion of the starch solution. Taken together, MPPs may have the potential as a functional supplement for blood glucose control and diabetes prevention. Full article
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