Bioactive Compounds in Bee Products: From Analysis to Health Benefits

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Nutraceuticals, Functional Foods, and Novel Foods".

Deadline for manuscript submissions: 10 June 2026 | Viewed by 1081

Special Issue Editor

College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
Interests: bee products; bioactive compounds; mycotoxins; fermented foods; synthetic biology

Special Issue Information

Dear Colleagues,

Bee products like honey, propolis, royal jelly, bee pollen, beeswax and bee venom are valued for nutritional and medicinal properties. These natural substances, rich in bioactive compounds such as polyphenols, flavonoids, peptides, enzymes and organic acids, have health-promoting properties like antioxidant and antimicrobial. But, the diversity, complexity and stability of these compounds during processing and digestion challenge functional research.

This Special Issue aims to connect ‘Chemical Analysis’ and ‘Health Benefits’ in bee product bioactive research. We welcome original research and reviews on these topics: (i) separation, identification, and quantitative analysis of bioactive compounds in bee products, (ii) investigation of in vitro and in vivo activity mechanisms, including antioxidant, antimicrobial, etc., (iii) studying in vivo metabolic fate of active ingredients and developing novel delivery systems for stability and bioavailability and (iv) developing methods using bioactive compound fingerprinting to authenticate bee product origin.

Through this Special Issue, we hope to fully elucidate the scientific basis for the exceptional health benefits of bee products and promote their innovative applications in functional foods, nutraceuticals and preventive medicine.

Dr. Jian Zhang
Guest Editor

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Keywords

  • bee products
  • bioactive compounds
  • separation
  • identification
  • in vitro and in vivo studies
  • analytical methods
  • health benefits
  • biological and functional activities
  • authenticity

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Published Papers (2 papers)

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Research

21 pages, 27851 KB  
Article
10-Hydroxy-2-decenoic Acid Suppresses Colorectal Cancer Progression by Inhibiting Wnt/β-Catenin Signaling and Promoting Apoptosis
by Yan Lin, Rongjing Cai, Lei Huang, Tianxing Lin, Anqi Lin, Zhenyu Lin, Shoujie Jiang, Yuqi Zhu, Yuan Yuan and Songkun Su
Foods 2026, 15(9), 1608; https://doi.org/10.3390/foods15091608 - 6 May 2026
Viewed by 318
Abstract
Colorectal cancer (CRC) remains a leading cause of cancer-related death worldwide, and advanced disease continues to show poor prognosis due to therapeutic limitations and drug resistance. Royal jelly (RJ), a natural functional food and dietary supplement, contains 10-hydroxy-2-decenoic acid (10-HDA), a bioactive fatty [...] Read more.
Colorectal cancer (CRC) remains a leading cause of cancer-related death worldwide, and advanced disease continues to show poor prognosis due to therapeutic limitations and drug resistance. Royal jelly (RJ), a natural functional food and dietary supplement, contains 10-hydroxy-2-decenoic acid (10-HDA), a bioactive fatty acid unique to RJ with demonstrated anticancer potential. This study evaluated the anti-CRC effects and underlying mechanisms of 10-HDA through cellular, animal, and transcriptomic approaches. 10-HDA markedly suppressed CRC cell viability with IC50 of 2.07 mM and 3.49 mM against HCT 116 and HT-29 cells, respectively, reduced gap closure by 29.30%, elevated intracellular reactive oxygen species (ROS), and attenuated xenograft tumor growth dose-dependently. Preliminary safety evaluation suggested that 10-HDA was well tolerated under the tested conditions, with no significant changes in body weight, serum AST, ALT, or ALP levels, or organ histology. Transcriptomic analysis showed significant enrichment of apoptosis and Wnt/β-catenin pathways. Molecular assessments indicated that 10-HDA was associated with alterations in apoptosis-related features, including increased caspase-3 activity, changes in Bcl-2 family proteins, and elevated ROS levels, as well as with modulation of the Wnt/β-catenin signaling pathway. These changes were consistent with enhanced β-catenin degradation and reduced nuclear translocation. It suggests that Wnt/β-catenin may be involved in the anti-CRC effects of 10-HDA. This study mechanistically clarifies the anti-CRC activity of 10-HDA as a natural food-derived bioactive compound, suggesting its therapeutic potential for Wnt/β-catenin dysregulated CRC. Full article
(This article belongs to the Special Issue Bioactive Compounds in Bee Products: From Analysis to Health Benefits)
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18 pages, 2437 KB  
Article
In Silico and In Vitro Screening and Mechanisms of Angiotensin I-Converting Enzyme Inhibitory Peptides from Protein Hydrolysates of Royal Jelly
by Ying Zhang, Shipeng Guo, Haoxiang Miao, Yafei Gu and Jian Zhang
Foods 2026, 15(9), 1536; https://doi.org/10.3390/foods15091536 - 29 Apr 2026
Viewed by 330
Abstract
This work focused on the identification of angiotensin I-converting enzyme (ACE) inhibitory peptides from royal jelly (RJ) proteins and elucidated their inhibition patterns and mechanisms. RJ proteins were analyzed for ACE inhibition potential using in silico tools, and suitable enzymes were selected for [...] Read more.
This work focused on the identification of angiotensin I-converting enzyme (ACE) inhibitory peptides from royal jelly (RJ) proteins and elucidated their inhibition patterns and mechanisms. RJ proteins were analyzed for ACE inhibition potential using in silico tools, and suitable enzymes were selected for peptide release. Hydrolysis conditions were optimized using response surface methodology (RSM), and the resulting peptides were fractionated and purified. Mass spectrometry identified 57 peptides, with seven selected for synthesis based on scoring. IDFDF, DVNFR, and SFHRL showed the highest ACE inhibition, with IC50 values of 16.9 μM, 42.5 μM, and 242.6 μM, respectively. Lineweaver–Burk plots revealed IDFDF as a competitive inhibitor, DVNFR as a non-competitive inhibitor, and SFHRL as a mixed inhibitor. Molecular docking indicated that peptide–ACE interactions were primarily mediated through hydrogen bonds and Zn(II) coordination. This work promotes the sustainable utilization of RJ and the development of ACE inhibitory peptides derived from food sources. Full article
(This article belongs to the Special Issue Bioactive Compounds in Bee Products: From Analysis to Health Benefits)
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