Beneficial Effects of Probiotics and Active Substances: Advanced Food and Human Health Applications

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Microbiology".

Deadline for manuscript submissions: closed (20 June 2025) | Viewed by 1546

Special Issue Editors


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Guest Editor
College of Food Science, Southwest University, Chongqing 400715, China
Interests: probiotic; functional food; bioactive; gut microbiota; fermented vegetables
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, China
Interests: polysaccharides; prebiotics; probiotics; gut microbiota; gut barrier
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Institute of Agro-Products Processing Science and Technology, Sichuan Academy of Agricultural Sciences, Chengdu 610066, China
Interests: fermented plant-based products; probiotics; prebiotics; functional metabolites from fermented plant-based products; postbiotics from fermented plant-based products; gut microbiota and fermented plant-based products

Special Issue Information

Dear Colleagues,

Probiotics are generally defined as “live microorganisms [that] could improve [the] host’s health when administrated at a certain amount”. Knowledge of probiotics originated from the health benefits of fermented products like beer, sauerkraut, yogurt, bread, and cheese. Indeed, these beneficial microorganisms could improve the flavor and texture of fermented foods, extend their shelf life, enhance their nutritional value, and produce health-promoting metabolites. Currently, probiotics are considered beneficial factors for foods or therapeutic interventions for various health conditions. This Special Issue aims to cover the most recent cutting-edge research on probiotic foods, including mining and evaluating novel strains for food, the interaction and synergistic effect of mixed starter strains, and the assessment of probiotic foods’ functional activity. Original research and reviews concerning prebiotics, natural active substances, and human health are also welcome.

We kindly invite you to contribute to this Special Issue.

Dr. Jichun Zhao
Dr. Chunqing Ai
Dr. Nan Zhao
Guest Editors

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Keywords

  • probiotics
  • gut microbiota
  • prebiotics
  • novel fermented food
  • food enrichment
  • starter culture
  • bioactive substances
  • gut barrier

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Published Papers (1 paper)

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Research

24 pages, 6281 KB  
Article
Bioactive Polysaccharides Prevent Lipopolysaccharide-Induced Intestinal Inflammation via Immunomodulation, Antioxidant Activity, and Microbiota Regulation
by Mingyang Gao, Wanqing Zhang, Yan Ma, Tingting Liu, Sijia Wang, Shuaihu Chen, Zhengli Wang and Hong Shen
Foods 2025, 14(15), 2575; https://doi.org/10.3390/foods14152575 - 23 Jul 2025
Viewed by 653
Abstract
Intestinal inflammation involves barrier impairment, immune hyperactivation, and oxidative stress imbalance. Bioactive polysaccharides universally alleviate inflammation via anti-inflammatory, antioxidant, and microbiota-modulating effects, yet exhibit distinct core mechanisms. Elucidating these differences is vital for targeted polysaccharide applications. This research examines distinct regulatory pathways through [...] Read more.
Intestinal inflammation involves barrier impairment, immune hyperactivation, and oxidative stress imbalance. Bioactive polysaccharides universally alleviate inflammation via anti-inflammatory, antioxidant, and microbiota-modulating effects, yet exhibit distinct core mechanisms. Elucidating these differences is vital for targeted polysaccharide applications. This research examines distinct regulatory pathways through which diverse bioactive polysaccharides mitigate lipopolysaccharide-triggered intestinal inflammation in male Kunming (KM) mice. This experiment employed Lentinula edodes polysaccharide (LNT), Auricularia auricula polysaccharide (AAP), Cordyceps militaris polysaccharide (CMP), Lycium barbarum polysaccharide (LBP), and Brassica rapa polysaccharide (BRP). The expression levels of biomarkers associated with the TLR4 signaling pathway, oxidative stress, and intestinal barrier function were quantified, along with comprehensive gut microbiota profiling. The results showed that all five polysaccharides alleviated inflammatory responses in mice by inhibiting inflammatory cytokine release, reducing oxidative damage, and modulating gut microbiota, but their modes of action differed: LBP significantly suppressed the TLR-4/MyD88 signaling pathway and its downstream pro-inflammatory cytokine expression, thereby blocking inflammatory signal transduction and reducing oxidative damage; LNT and CMP enhanced the body’s antioxidant capacity by increasing antioxidant enzyme activities and decreasing malondialdehyde (MDA) levels; AAP and BRP enriched Akkermansia (Akk.) within the Verrucomicrobia (Ver.) phylum, upregulating tight junction protein expression to strengthen the intestinal mucosal barrier and indirectly reduce oxidative damage. This research demonstrates that different polysaccharides alleviate inflammation through multi-target synergistic mechanisms: LBP primarily inhibits inflammatory pathways; AAP and BRP focus on intestinal barrier protection and microbiota modulation; and LNT and CMP exert effects via antioxidant enzyme activation. These data support designing polysaccharide blends that leverage complementary inflammatory modulation mechanisms. Full article
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