Emulsion-Based Encapsulation and Delivery Systems for Bioactive Compounds in Functional Foods

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Nutraceuticals, Functional Foods, and Novel Foods".

Deadline for manuscript submissions: 15 June 2026 | Viewed by 604

Special Issue Editors


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Guest Editor
Department of Biotechnology and Food Science, University of Burgos, Plaza Misael Bañuelos s/n, 09001 Burgos, Spain
Interests: membrane processes; emulsion formulation and characterization; recovery of bioactive compounds from agri-food wastes; encapsulation in colloidal delivery

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Guest Editor
Department of Biotechnology and Food Science, University of Burgos, Plaza Misael Bañuelos s/n, 09001 Burgos, Spain
Interests: extraction and formulation processes of bioactive ingredients (pectin, proteins, phenolics), omega-3 encapsulation, supercritical CO2 processes for extraction and formulation, emulsification processes intensification, biomass valorization

Special Issue Information

Dear Colleagues,

Bioactive compounds (polyphenols, essential oils, omega–3 polyunsaturated fatty acids, vitamins, etc.) have received increasing attention due to their nutritional and health-promoting properties. Despite their potential benefits, the practical application of these compounds remains challenging due to their low bioavailability and susceptibility to degradation under adverse environmental conditions, particularly exposure to light and high temperatures.

To address these limitations, emulsions have been widely used in food systems for the encapsulation of different bioactive compounds in order to improve their stability and bioavailability. Moreover, emulsions facilitate controlled release mechanisms, further expanding their applicability in the development of innovative functional foods and beverages.

This Special Issue invites submissions of high-quality review papers and original research articles that explore the preparation and application of diverse emulsion-based systems—including single emulsions, double emulsions, Pickering emulsions, and emulsion gels—as encapsulation and delivery platforms for bioactive compounds, with potential applications in functional foods and beverages.

Prof. Dr. José M. Benito
Dr. Óscar Benito-Román
Guest Editors

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Keywords

  • oil-in-water (O/W) and water-in-oil (W/O) emulsions
  • digestion of the O/W and W/O emulsion carriers
  • double emulsions
  • pickering emulsions
  • bioactive compounds
  • polyphenols
  • omega-3 polyunsaturated fatty acids
  • encapsulation
  • delivery systems
  • functional foods and beverages

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Published Papers (1 paper)

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Research

16 pages, 2080 KB  
Article
Triacylglycerol Crystallinity and Emulsion Colloidal Acid Stability Influence In Vitro Digestion Lipolysis and Bioaccessibility of Long-Chain Omega-3 Fatty Acid-Rich Nanoemulsions
by Jessica D. Ulbikas, Saeed Mirzaee Ghazani, Alejandro G. Marangoni and Amanda J. Wright
Foods 2025, 14(21), 3631; https://doi.org/10.3390/foods14213631 (registering DOI) - 24 Oct 2025
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Abstract
This study investigated the relationships between emulsion droplet triacylglycerol (TAG) crystallinity and colloidal acid stability on in vitro digestion microstructure, lipolysis, and docosahexaenoic acid (DHA) bioaccessibility. Oil-in-water (o/w) nanoemulsions (20 wt%) composed of 50/50 DHA-rich algal oil with either palm stearin (PS) or [...] Read more.
This study investigated the relationships between emulsion droplet triacylglycerol (TAG) crystallinity and colloidal acid stability on in vitro digestion microstructure, lipolysis, and docosahexaenoic acid (DHA) bioaccessibility. Oil-in-water (o/w) nanoemulsions (20 wt%) composed of 50/50 DHA-rich algal oil with either palm stearin (PS) or olein (PO), and either acid-stable Tween 80 (2.0 wt%; AS) or acid-unstable soy lecithin (2.2 wt%; AU) were fast or slow cooled to 37 °C after microfluidization. Similar particle size distributions and D3,2 (~131–142 nm) and D4,3 (~208–239 nm) values were achieved. All emulsions were highly electronegative (~−45–70 mV) and differences (p < 0.05) were due to emulsifier type, as expected, and cooling rate. Next, emulsions were subjected to INFOGEST in vitro digestion for analysis of intestinal lipolysis by free fatty acid titration and DHA bioaccessibility. As expected, AU emulsions flocculated, forming larger aggregates during the gastric phase. Slower lipolysis was observed for the AU emulsions (p < 0.05), attributed to gastric phase aggregation, and lower 2 h lipolysis was observed for the PS emulsions (~74–77%) based on the presence of crystallinity. DHA bioaccessibility was high (~57–88%), especially for the AS emulsions (p < 0.05). Therefore, emulsion colloidal acid stability and TAG physical state significantly impacted emulsion gastric microstructure, digestion, and bioaccessibility. Full article
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